Encapsulation of proteins in chitosan particles using various cross-linking agents and their characterization

Masahiro Niwa, Toshinori Sato

Research output: Contribution to conferencePaper

Abstract

In order to improve the stability of protein in vivo, protein/polymer complexes has been employed. Chitosan, the natural polysaccharides, has many valuable properties such as biocompatibility and biodegradability. The conventional protein/chitosan particles were easily destroyed by the pH change and the addition of salt. Therefore we employed cross-linking agents such as genipin and glutaraldehyde and tried to improve the stability of chitosan particles. Characterization of protein/chitosan/cross-linking agent particles was carried out by measurement of particle size and turbidity. The particles cross-linked with genipin showed the high stability under high salt concentration and low pH.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005 Dec 1
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: 2005 May 252005 May 27

Other

Other54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period05/5/2505/5/27

Keywords

  • Chitosan
  • Cross-linking agent
  • Drug delivery system
  • Genipin
  • Particle

ASJC Scopus subject areas

  • Engineering(all)

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    Niwa, M., & Sato, T. (2005). Encapsulation of proteins in chitosan particles using various cross-linking agents and their characterization. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.