Abstract
In order to improve the stability of protein in vivo, protein/polymer complexes has been employed. Chitosan, the natural polysaccharides, has many valuable properties such as biocompatibility and biodegradability. The conventional protein/chitosan particles were easily destroyed by the pH change and the addition of salt. Therefore we employed cross-linking agents such as genipin and glutaraldehyde and tried to improve the stability of chitosan particles. Characterization of protein/chitosan/cross-linking agent particles was carried out by measurement of particle size and turbidity. The particles cross-linked with genipin showed the high stability under high salt concentration and low pH.
| Original language | English |
|---|---|
| Number of pages | 1 |
| Publication status | Published - 2005 Dec 1 |
| Event | 54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: 2005 May 25 → 2005 May 27 |
Other
| Other | 54th SPSJ Annual Meeting 2005 |
|---|---|
| Country/Territory | Japan |
| City | Yokohama |
| Period | 05/5/25 → 05/5/27 |
Keywords
- Chitosan
- Cross-linking agent
- Drug delivery system
- Genipin
- Particle
ASJC Scopus subject areas
- Engineering(all)