Endocrine functions of bile acids

Sander M. Houten, Mitsuhiro Watanabe, Johan Auwerx

Research output: Contribution to journalArticle

351 Citations (Scopus)

Abstract

Bile acids (BAs), a group of structurally diverse molecules that are primarily synthesized in the liver from cholesterol, are the chief components of bile. Besides their well-established roles in dietary lipid absorption and cholesterol homeostasis, it has recently emerged that BAs are also signaling molecules, with systemic endocrine functions. BAs activate mitogen-activated protein kinase pathways, are ligands for the G-protein-coupled receptor TGR5, and activate nuclear hormone receptors such as farnesoid X receptor α. Through activation of these diverse signaling pathways, BAs can regulate their own enterohepatic circulation, but also triglyceride, cholesterol, energy, and glucose homeostasis. Thus, BA-controlled signaling pathways are promising novel drug targets to treat common metabolic diseases, such as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.

Original languageEnglish
Pages (from-to)1419-1425
Number of pages7
JournalEMBO Journal
Volume25
Issue number7
DOIs
Publication statusPublished - 2006 Apr 5
Externally publishedYes

Fingerprint

Bile Acids and Salts
Cholesterol
Homeostasis
Enterohepatic Circulation
Molecules
Metabolic Diseases
Cytoplasmic and Nuclear Receptors
Medical problems
G-Protein-Coupled Receptors
Mitogen-Activated Protein Kinases
Hyperlipidemias
Bile
Liver
Type 2 Diabetes Mellitus
Atherosclerosis
Triglycerides
Obesity
Chemical activation
Ligands
Lipids

Keywords

  • Bile acids
  • Gene expression
  • Metabolism
  • Nuclear receptors
  • Signaling

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

Cite this

Endocrine functions of bile acids. / Houten, Sander M.; Watanabe, Mitsuhiro; Auwerx, Johan.

In: EMBO Journal, Vol. 25, No. 7, 05.04.2006, p. 1419-1425.

Research output: Contribution to journalArticle

Houten, SM, Watanabe, M & Auwerx, J 2006, 'Endocrine functions of bile acids', EMBO Journal, vol. 25, no. 7, pp. 1419-1425. https://doi.org/10.1038/sj.emboj.7601049
Houten, Sander M. ; Watanabe, Mitsuhiro ; Auwerx, Johan. / Endocrine functions of bile acids. In: EMBO Journal. 2006 ; Vol. 25, No. 7. pp. 1419-1425.
@article{0a400f4dabe04a5aaaa3a097f9ed06d9,
title = "Endocrine functions of bile acids",
abstract = "Bile acids (BAs), a group of structurally diverse molecules that are primarily synthesized in the liver from cholesterol, are the chief components of bile. Besides their well-established roles in dietary lipid absorption and cholesterol homeostasis, it has recently emerged that BAs are also signaling molecules, with systemic endocrine functions. BAs activate mitogen-activated protein kinase pathways, are ligands for the G-protein-coupled receptor TGR5, and activate nuclear hormone receptors such as farnesoid X receptor α. Through activation of these diverse signaling pathways, BAs can regulate their own enterohepatic circulation, but also triglyceride, cholesterol, energy, and glucose homeostasis. Thus, BA-controlled signaling pathways are promising novel drug targets to treat common metabolic diseases, such as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.",
keywords = "Bile acids, Gene expression, Metabolism, Nuclear receptors, Signaling",
author = "Houten, {Sander M.} and Mitsuhiro Watanabe and Johan Auwerx",
year = "2006",
month = "4",
day = "5",
doi = "10.1038/sj.emboj.7601049",
language = "English",
volume = "25",
pages = "1419--1425",
journal = "EMBO Journal",
issn = "0261-4189",
publisher = "Nature Publishing Group",
number = "7",

}

TY - JOUR

T1 - Endocrine functions of bile acids

AU - Houten, Sander M.

AU - Watanabe, Mitsuhiro

AU - Auwerx, Johan

PY - 2006/4/5

Y1 - 2006/4/5

N2 - Bile acids (BAs), a group of structurally diverse molecules that are primarily synthesized in the liver from cholesterol, are the chief components of bile. Besides their well-established roles in dietary lipid absorption and cholesterol homeostasis, it has recently emerged that BAs are also signaling molecules, with systemic endocrine functions. BAs activate mitogen-activated protein kinase pathways, are ligands for the G-protein-coupled receptor TGR5, and activate nuclear hormone receptors such as farnesoid X receptor α. Through activation of these diverse signaling pathways, BAs can regulate their own enterohepatic circulation, but also triglyceride, cholesterol, energy, and glucose homeostasis. Thus, BA-controlled signaling pathways are promising novel drug targets to treat common metabolic diseases, such as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.

AB - Bile acids (BAs), a group of structurally diverse molecules that are primarily synthesized in the liver from cholesterol, are the chief components of bile. Besides their well-established roles in dietary lipid absorption and cholesterol homeostasis, it has recently emerged that BAs are also signaling molecules, with systemic endocrine functions. BAs activate mitogen-activated protein kinase pathways, are ligands for the G-protein-coupled receptor TGR5, and activate nuclear hormone receptors such as farnesoid X receptor α. Through activation of these diverse signaling pathways, BAs can regulate their own enterohepatic circulation, but also triglyceride, cholesterol, energy, and glucose homeostasis. Thus, BA-controlled signaling pathways are promising novel drug targets to treat common metabolic diseases, such as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.

KW - Bile acids

KW - Gene expression

KW - Metabolism

KW - Nuclear receptors

KW - Signaling

UR - http://www.scopus.com/inward/record.url?scp=33645738747&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645738747&partnerID=8YFLogxK

U2 - 10.1038/sj.emboj.7601049

DO - 10.1038/sj.emboj.7601049

M3 - Article

C2 - 16541101

AN - SCOPUS:33645738747

VL - 25

SP - 1419

EP - 1425

JO - EMBO Journal

JF - EMBO Journal

SN - 0261-4189

IS - 7

ER -