@article{2f23afab199f4d0897ea1da48001cc84,
title = "Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth",
abstract = "The microbiota has been shown to promote intestinal tumourigenesis, but a possible anti-tumourigenic effect has also been postulated. Here, we demonstrate that changes in the microbiota and mucus composition are concomitant with tumourigenesis. We identified two anti-tumourigenic strains of the microbiota—Faecalibaculum rodentium and its human homologue, Holdemanella biformis—that are strongly under-represented during tumourigenesis. Reconstitution of ApcMin/+ or azoxymethane- and dextran sulfate sodium-treated mice with an isolate of F. rodentium (F. PB1) or its metabolic products reduced tumour growth. Both F. PB1 and H. biformis produced short-chain fatty acids that contributed to control protein acetylation and tumour cell proliferation by inhibiting calcineurin and NFATc3 activation in mouse and human settings. We have thus identified endogenous anti-tumourigenic bacterial strains with strong diagnostic, therapeutic and translational potential.",
author = "Elena Zagato and Chiara Pozzi and Alice Bertocchi and Tiziana Schioppa and Fabiana Saccheri and Silvia Guglietta and Bruno Fosso and Laura Melocchi and Giulia Nizzoli and Jacopo Troisi and Marinella Marzano and Bianca Oresta and Ilaria Spadoni and Koji Atarashi and Sara Carloni and Stefania Arioli and Giulia Fornasa and Francesco Asnicar and Nicola Segata and Simone Guglielmetti and Kenya Honda and Graziano Pesole and William Vermi and Giuseppe Penna and Maria Rescigno",
note = "Funding Information: We thank M. Bugatti and S. Licini (supported by Fondazione Beretta, Brescia, Italy) for their technical support in the histological analyses; A. Thomas and E. Pasolli for performing the bioinformatics analyses; C. Faccani for technical support for the in vitro experiments; and E. Mileti, C. Burrello and M. R. Giuffr{\'e} for their technical support for the in vivo experiments. This work has been supported by grants from the Italian Association for Cancer Research (grant no. AIRC IG 17628) and the European Research council (grant no. 615735, HOMEOGUT ERC) to M.R. E.Z., I.S. and A.B. were/are recipients of a FIRC fellowship. T.S. is a recipient of a fellowship from Fondazione Veronesi. G.F. is a recipient of a grant from the Italian Ministry of Health (grant no. GR-2013-02359806). Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature Limited.",
year = "2020",
month = mar,
day = "1",
doi = "10.1038/s41564-019-0649-5",
language = "English",
volume = "5",
pages = "511--524",
journal = "Nature Microbiology",
issn = "2058-5276",
publisher = "Nature Publishing Group",
number = "3",
}