Endometrial cancer and hypermethylation

Regulation of DNA and MicroRNA by epigenetics

Kouji Banno, Iori Kisu, Megumi Yanokura, Kenta Masuda, Yusuke Kobayashi, Arisa Ueki, Kosuke Tsuji, Wataru Yamagami, Hiroyuki Nomura, Nobuyuki Susumu, Daisuke Aoki

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Endometrial cancer is the seventh most common cancer in women worldwide. Therefore elucidation of the pathogenesis and development of effective treatment for endometrial cancer are important. However, several aspects of the mechanism of carcinogenesis in the endometrium remain unclear. Associations with genetic variation and mutations of cancer-related genes have been shown, but these do not provide a complete explanation. Therefore, in recent years, epigenetic mechanisms that do not involve changes in DNA sequences have been examined. Studies aimed at detection of aberrant DNA hypermethylation in cancer cells present in microscopic amounts in vivo and application of the results to cancer diagnosis have also started. Breakdown of the DNA mismatch repair mechanism is thought to play a large role in the development of endometrial cancer, with changes in the expression of the hMLH1 gene being particularly important. Silencing of genes such as APC and CHFR, Sprouty 2, RASSF1A, GPR54, CDH1, and RSK4 by DNA hypermethylation, onset of Lynch syndrome due to hereditary epimutation of hMLH1 and hMSH2 mismatch repair genes, and regulation of gene expression by microRNAs may also underlie the carcinogenic mechanisms of endometrial cancer. Further understanding of these issues may permit development of new therapies.

Original languageEnglish
Article number738274
JournalBiochemistry Research International
DOIs
Publication statusPublished - 2012

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Endometrial Neoplasms
MicroRNAs
Epigenomics
Genes
DNA Mismatch Repair
DNA
Repair
Hereditary Nonpolyposis Colorectal Neoplasms
Neoplasms
Neoplasm Genes
DNA sequences
Gene Expression Regulation
Gene Silencing
Endometrium
Gene expression
Carcinogenesis
Cells
Gene Expression
Mutation
Therapeutics

ASJC Scopus subject areas

  • Biochemistry

Cite this

Endometrial cancer and hypermethylation : Regulation of DNA and MicroRNA by epigenetics. / Banno, Kouji; Kisu, Iori; Yanokura, Megumi; Masuda, Kenta; Kobayashi, Yusuke; Ueki, Arisa; Tsuji, Kosuke; Yamagami, Wataru; Nomura, Hiroyuki; Susumu, Nobuyuki; Aoki, Daisuke.

In: Biochemistry Research International, 2012.

Research output: Contribution to journalArticle

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