Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion

Masaya Ueno, Katsuhide Igarashi, Naoki Kimura, Keisuke Okita, Makiko Takizawa, Ikuo Nobuhisa, Tetsuo Kojima, Toshio Kitamura, Ulrike Samulowitz, Dietmar Vestweber, Taizo Shimomura, Toshio Suda, Kinichi Nakashima, Tetsuya Taga

Research output: Contribution to journalArticle

7 Citations (Scopus)


Recent studies have suggested the existence of progenitors common to hematopoietic and endothelial cells, called hemangioblasts, in, for instance, embryonic dorsal aorta. To identify a membrane-bound or secretory molecule regulating early hematopoiesis, we screened a cDNA library from dorsal aortas of embryonic day (E) 10.5 mice by a signal sequence trap method and obtained a clone encoding a sialoprotein, endomucin-1. Immunohistochemistry revealed that the endomucin-1 transcript was specifically expressed in the endothelial cells of dorsal aorta of E10.5 mouse embryo. Overexpression of endomucin-1 strongly inhibited adhesion and aggregation of cells, including cultured endothelial cells from E10.5 dorsal aorta. These data suggest that endomucin-1 may play a role in detachment of hematopoietic cells from endothelium during early hematopoiesis.

Original languageEnglish
Pages (from-to)501-506
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number2
Publication statusPublished - 2001 Sep 21
Externally publishedYes


  • Aorta-gonad-mesonephros
  • Cell adhesion
  • Cell aggregation
  • Endomucin
  • Endothelial cells
  • Hemangioblasts
  • Hematopoiesis
  • Hematopoietic stem cells
  • Sialomucin
  • Signal sequence trap

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion'. Together they form a unique fingerprint.

  • Cite this

    Ueno, M., Igarashi, K., Kimura, N., Okita, K., Takizawa, M., Nobuhisa, I., Kojima, T., Kitamura, T., Samulowitz, U., Vestweber, D., Shimomura, T., Suda, T., Nakashima, K., & Taga, T. (2001). Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion. Biochemical and Biophysical Research Communications, 287(2), 501-506. https://doi.org/10.1006/bbrc.2001.5587