Endoscopic and Clinicopathological Features of Superficial Non-Ampullary Duodenal Tumor Based on the Mucin Phenotypes

Yoichi Akazawa, Hiroya Ueyama, Sho Tsuyama, Atsushi Ikeda, Noboru Yatagai, Hiroyuki Komori, Tsutomu Takeda, Kohei Matsumoto, Kenshi Matsumoto, Takashi Hashimoto, Natsumi Tomita, Yoshiaki Kajiyama, Motohiko Kato, Takashi Yao, Akihito Nagahara

Research output: Contribution to journalArticle

Abstract

Aims: We aimed to clarify the endoscopic/clinicopathological features of superficial non-ampullary duodenal epithelial tumors (SNADETs) based on their mucin phenotypes. Methods: We analyzed 62 SNADET lesions and classified them based on mucin phenotypic expression. Endoscopic and clinicopathological findings were compared according to mucin phenotypes. Results: Eleven lesions had the gastric phenotype (GP) and 43 lesions had the intestinal phenotype (IP). All GP lesions were located in the first portion of the duodenum, while most IP lesions (72.1%) were located in the second portion (p < 0.01). Tumor size was significantly larger in the GP than in the IP group (14.4 mm vs. 10.2 mm, p < 0.05). Reddish color (72.7% in GP vs. 37.2% in IP, p < 0.05), type 0-I (72.7% vs. 11.6%, p < 0.01), lobular/granular pattern (81.8% vs. 4.7%, p < 0.01), and category 4/5 in Vienna classification (81.8% vs. 30.2%, p < 0.01) were observed significantly more often in the GP than in the IP group. Regarding findings of magnifying endoscopy with narrow-band imaging (M-NBI), white opaque substance (22.2% in GP vs. 89.7% in IP, p < 0.01) and light blue crest (0% vs. 43.6%, p < 0.05) were significantly less frequently observed in the GP group. Oval-shaped marginal epithelium (66.7% vs. 17.9%, p < 0.01), dense pattern (55.6% vs. 2.6%, p < 0.01), and dilatation of the intervening part (100% vs. 12.8%, p < 0.01) were more frequently observed in the GP group. Conclusions: SNADETs showed distinct endoscopic/clinicopathological features according to the mucin phenotype. Tumor location, coloration, macroscopic type, and endoscopic findings including M-NBI are useful to distinguish the mucin phenotypes of SNADETs.

Original languageEnglish
JournalDigestion
DOIs
Publication statusAccepted/In press - 2020

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Endoscopic and Clinicopathological Features of Superficial Non-Ampullary Duodenal Tumor Based on the Mucin Phenotypes'. Together they form a unique fingerprint.

  • Cite this

    Akazawa, Y., Ueyama, H., Tsuyama, S., Ikeda, A., Yatagai, N., Komori, H., Takeda, T., Matsumoto, K., Matsumoto, K., Hashimoto, T., Tomita, N., Kajiyama, Y., Kato, M., Yao, T., & Nagahara, A. (Accepted/In press). Endoscopic and Clinicopathological Features of Superficial Non-Ampullary Duodenal Tumor Based on the Mucin Phenotypes. Digestion. https://doi.org/10.1159/000508040