自己免疫性水疱症の上部消化管内視鏡所見

Translated title of the contribution: Endoscopic findings of laryngopharyngeal and esophageal involvement in autoimmune bullous disease

Research output: Contribution to journalArticle

Abstract

Background and Aim: Autoimmune bullous disease (ABD) is induced by autoantibodies against cell adhesion molecules, and blistering may occur on the mucous membranes of the eyes, nose, mouth, oral cavity, laryngopharynx, and esophagus. Endoscopic prevalence and features of ABD-associated esophageal lesions are not well known. We conducted the present study to assess the endoscopic prevalence of ABD-associated mucosal lesions. Methods: Endoscopic prevalence of mucosal lesions, particularly laryngopharyngeal and esophageal lesions, was used as the primary endpoint to assess the significance of upper gastrointestinal endoscopy, and clinical and endoscopic features were secondary endpoints. Results: Of 123 ABD patients, 50.4% had apparent oral or laryngopharyngeal lesions and 30.8%had laryngopharyngeal lesions. Esophageal lesions were detected through normal observation in 16.8% of affected patients, whereas 40.6% exhibited epidermolysis or blood blisters by mechanical inducement, regardless of esophageal mucosal lesion detection by normal observation. Additionally, 56.0% exhibited the Nikolsky sign with mechanical inducement. Of the 123 patients, 29.2% did not have exposed skin lesions. Of these patients, 77.7% had oral cavity or laryngopharyngeal lesions, 36.1% had esophageal lesions, and 58.3% exhibited the Nikolsky sign on esophageal mucosa. Conclusion: It is important to determine the endoscopic characteristics and findings of ABD. ABD can be suspected from endoscopic findings.

Original languageJapanese
Pages (from-to)1515-1526
Number of pages12
JournalGastroenterological Endoscopy
Volume60
Issue number8
Publication statusPublished - 2018 Aug 1

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Autoimmune Diseases
Mouth
Observation
Hypopharynx
Gastrointestinal Endoscopy
Cell Adhesion Molecules
Blister
Nose
Autoantibodies
Esophagus
Mucous Membrane
Skin

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

自己免疫性水疱症の上部消化管内視鏡所見. / Nakamura, Rieko; Omori, Tai; Suda, Koichi; Wada, Norihito; Kawakubo, Hirofumi; Takeuchi, Hiroya; Yamagami, Jun; Amagai, Masayuki; Kitagawa, Yuukou.

In: Gastroenterological Endoscopy, Vol. 60, No. 8, 01.08.2018, p. 1515-1526.

Research output: Contribution to journalArticle

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AU - Wada, Norihito

AU - Kawakubo, Hirofumi

AU - Takeuchi, Hiroya

AU - Yamagami, Jun

AU - Amagai, Masayuki

AU - Kitagawa, Yuukou

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