Endoscopic submucosal dissection as a treatment for gastric noninvasive neoplasia: A multicenter study by Osaka University ESD Study Group

Motohiko Kato, Tsutomu Nishida, Shusaku Tsutsui, Masato Komori, Tomoki Michida, Katsumi Yamamoto, Naoki Kawai, Shinji Kitamura, Shinichiro Zushi, Akihiro Nishihara, Fumihiko Nakanishi, Kazuo Kinoshita, Takuya Yamada, Hideki Iijima, Masahiko Tsujii, Norio Hayashi

Research output: Contribution to journalArticle

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Abstract

Background: Treatment with endoscopic submucosal dissection (ESD) for gastric noninvasive neoplasia (NIN) diagnosed by endoscopic forceps biopsy specimen, whether as a follow-up or "total incisional biopsy", is controversial. To validate the use of ESD for total incisional biopsy in NIN, we examined the underdiagnosis rate of NIN and the rates of complication associated with ESD. Methods: This is a cross-sectional multicenter retrospective study from 10 hospitals. Subjects diagnosed with NIN (equivalent to category 3 or 4.1 of the Vienna classification) by endoscopic forceps biopsy and treated with ESD were included. From March 2003 to December 2009, a total of 468 subjects were included and analyzed. The underdiagnosis rate was defined as the proportion of lesions diagnosed with adenocarcinoma after ESD. We assessed the complete en-bloc resection rate and the complication rate of ESD. Results: Among the 468 subjects with NIN, 205 were diagnosed with adenocarcinoma after ESD, with an underdiagnosis rate of 44% (95% confidence interval: 39-49%). Two submucosal cancer lesions had invaded beyond 500 μm and one had lymphatic involvement. The complete en-bloc resection rate was 97%. The incidences of post-ESD bleeding, perforation, and serious complications were 5.5, 4.7, and 0.43%, respectively. There were no procedure-related deaths. Conclusions: In this large-scale, multicenter cross-sectional study, over 40% of the noninvasive gastric neoplasia specimens were determined to have adenocarcinoma, and the ESD-related complication rate was relatively low. Therefore, ESD was useful and may be a therapeutic option for gastric NIN.

Original languageEnglish
Pages (from-to)325-331
Number of pages7
JournalJournal of Gastroenterology
Volume46
Issue number3
DOIs
Publication statusPublished - 2011 Mar 1
Externally publishedYes

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Multicenter Studies
Stomach
Neoplasms
Biopsy
Adenocarcinoma
Surgical Instruments
Endoscopic Mucosal Resection
Retrospective Studies
Cross-Sectional Studies
Confidence Intervals
Hemorrhage
Incidence

Keywords

  • Adenoma
  • ESD
  • Gastric
  • Noninvasive neoplasia

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Endoscopic submucosal dissection as a treatment for gastric noninvasive neoplasia : A multicenter study by Osaka University ESD Study Group. / Kato, Motohiko; Nishida, Tsutomu; Tsutsui, Shusaku; Komori, Masato; Michida, Tomoki; Yamamoto, Katsumi; Kawai, Naoki; Kitamura, Shinji; Zushi, Shinichiro; Nishihara, Akihiro; Nakanishi, Fumihiko; Kinoshita, Kazuo; Yamada, Takuya; Iijima, Hideki; Tsujii, Masahiko; Hayashi, Norio.

In: Journal of Gastroenterology, Vol. 46, No. 3, 01.03.2011, p. 325-331.

Research output: Contribution to journalArticle

Kato, M, Nishida, T, Tsutsui, S, Komori, M, Michida, T, Yamamoto, K, Kawai, N, Kitamura, S, Zushi, S, Nishihara, A, Nakanishi, F, Kinoshita, K, Yamada, T, Iijima, H, Tsujii, M & Hayashi, N 2011, 'Endoscopic submucosal dissection as a treatment for gastric noninvasive neoplasia: A multicenter study by Osaka University ESD Study Group', Journal of Gastroenterology, vol. 46, no. 3, pp. 325-331. https://doi.org/10.1007/s00535-010-0350-1
Kato, Motohiko ; Nishida, Tsutomu ; Tsutsui, Shusaku ; Komori, Masato ; Michida, Tomoki ; Yamamoto, Katsumi ; Kawai, Naoki ; Kitamura, Shinji ; Zushi, Shinichiro ; Nishihara, Akihiro ; Nakanishi, Fumihiko ; Kinoshita, Kazuo ; Yamada, Takuya ; Iijima, Hideki ; Tsujii, Masahiko ; Hayashi, Norio. / Endoscopic submucosal dissection as a treatment for gastric noninvasive neoplasia : A multicenter study by Osaka University ESD Study Group. In: Journal of Gastroenterology. 2011 ; Vol. 46, No. 3. pp. 325-331.
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T1 - Endoscopic submucosal dissection as a treatment for gastric noninvasive neoplasia

T2 - A multicenter study by Osaka University ESD Study Group

AU - Kato, Motohiko

AU - Nishida, Tsutomu

AU - Tsutsui, Shusaku

AU - Komori, Masato

AU - Michida, Tomoki

AU - Yamamoto, Katsumi

AU - Kawai, Naoki

AU - Kitamura, Shinji

AU - Zushi, Shinichiro

AU - Nishihara, Akihiro

AU - Nakanishi, Fumihiko

AU - Kinoshita, Kazuo

AU - Yamada, Takuya

AU - Iijima, Hideki

AU - Tsujii, Masahiko

AU - Hayashi, Norio

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Background: Treatment with endoscopic submucosal dissection (ESD) for gastric noninvasive neoplasia (NIN) diagnosed by endoscopic forceps biopsy specimen, whether as a follow-up or "total incisional biopsy", is controversial. To validate the use of ESD for total incisional biopsy in NIN, we examined the underdiagnosis rate of NIN and the rates of complication associated with ESD. Methods: This is a cross-sectional multicenter retrospective study from 10 hospitals. Subjects diagnosed with NIN (equivalent to category 3 or 4.1 of the Vienna classification) by endoscopic forceps biopsy and treated with ESD were included. From March 2003 to December 2009, a total of 468 subjects were included and analyzed. The underdiagnosis rate was defined as the proportion of lesions diagnosed with adenocarcinoma after ESD. We assessed the complete en-bloc resection rate and the complication rate of ESD. Results: Among the 468 subjects with NIN, 205 were diagnosed with adenocarcinoma after ESD, with an underdiagnosis rate of 44% (95% confidence interval: 39-49%). Two submucosal cancer lesions had invaded beyond 500 μm and one had lymphatic involvement. The complete en-bloc resection rate was 97%. The incidences of post-ESD bleeding, perforation, and serious complications were 5.5, 4.7, and 0.43%, respectively. There were no procedure-related deaths. Conclusions: In this large-scale, multicenter cross-sectional study, over 40% of the noninvasive gastric neoplasia specimens were determined to have adenocarcinoma, and the ESD-related complication rate was relatively low. Therefore, ESD was useful and may be a therapeutic option for gastric NIN.

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KW - Adenoma

KW - ESD

KW - Gastric

KW - Noninvasive neoplasia

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