Endoscopic submucosal dissection for rectal epithelial neoplasia

M. Fujishiro, Naohisa Yahagi, M. Nakamura, N. Kakushima, S. Kodashima, S. Ono, K. Kobayashi, T. Hashimoto, N. Yamamichi, A. Tateishi, Y. Shimizu, M. Oka, K. Ogura, T. Kawabe, M. Ichinose, M. Omata

Research output: Contribution to journalArticle

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Abstract

Background and Study Aims: The technique of endoscopic submucosal dissection (ESD) has recently been developed for enbloc resection of gastric tumors. For oncological reasons and in order to improve the patients' quality of life, it may be desirable to use the same technique for rectal neoplasia. Patients and Methods: Thirty-five consecutive patients with rectal neoplasia who had a preoperative diagnosis of large intraepithelial neoplasias with submucosal fibrosis or located on the rectal folds were enrolled. ESD was carried out with the same technique previously described for the stomach, with some modifications. The efficacy, complications, and follow-up results of the treatment were assessed. Results: The rates of en-bloc resection and en-bloc plus RO resection were 88.6% (31 of 35) and 62.9% (22 of 35), respectively. Hemoglobin levels did not drop by more than 2 g/dl in any of the patients after ESD. None of the patients had to receive blood transfusions or undergo emergency colonoscopy due to bleeding during ESD or hematochezia after ESD. Perforation during ESD occurred in two patients (5.7%), who were managed with conservative medical treatment after endoscopic closure of the perforation. Excluding three patients in whom additional surgery was carried out, all but one of 32 patients were free of recurrence during a mean follow-up period of 36 months (range 12-60 months). The exception was a patient in whom a multiple-piece resection was required; the recurrent (residual) tumor, found 2 months after ESD, was a small adenoma that was again treated endoscopically. Conclusions: ESD is applicable in the rectum with promising results, but the technique is still at a developmental stage and patients should be informed of the potential risks.

Original languageEnglish
Pages (from-to)493-497
Number of pages5
JournalEndoscopy
Volume38
Issue number5
DOIs
Publication statusPublished - 2006 May
Externally publishedYes

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Neoplasms
Stomach
Endoscopic Mucosal Resection
Gastrointestinal Hemorrhage
Residual Neoplasm
Colonoscopy
Rectum
Blood Transfusion
Adenoma
Hemoglobins
Emergencies
Fibrosis
Quality of Life
Hemorrhage
Recurrence
Therapeutics

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Fujishiro, M., Yahagi, N., Nakamura, M., Kakushima, N., Kodashima, S., Ono, S., ... Omata, M. (2006). Endoscopic submucosal dissection for rectal epithelial neoplasia. Endoscopy, 38(5), 493-497. https://doi.org/10.1055/s-2006-925398

Endoscopic submucosal dissection for rectal epithelial neoplasia. / Fujishiro, M.; Yahagi, Naohisa; Nakamura, M.; Kakushima, N.; Kodashima, S.; Ono, S.; Kobayashi, K.; Hashimoto, T.; Yamamichi, N.; Tateishi, A.; Shimizu, Y.; Oka, M.; Ogura, K.; Kawabe, T.; Ichinose, M.; Omata, M.

In: Endoscopy, Vol. 38, No. 5, 05.2006, p. 493-497.

Research output: Contribution to journalArticle

Fujishiro, M, Yahagi, N, Nakamura, M, Kakushima, N, Kodashima, S, Ono, S, Kobayashi, K, Hashimoto, T, Yamamichi, N, Tateishi, A, Shimizu, Y, Oka, M, Ogura, K, Kawabe, T, Ichinose, M & Omata, M 2006, 'Endoscopic submucosal dissection for rectal epithelial neoplasia', Endoscopy, vol. 38, no. 5, pp. 493-497. https://doi.org/10.1055/s-2006-925398
Fujishiro M, Yahagi N, Nakamura M, Kakushima N, Kodashima S, Ono S et al. Endoscopic submucosal dissection for rectal epithelial neoplasia. Endoscopy. 2006 May;38(5):493-497. https://doi.org/10.1055/s-2006-925398
Fujishiro, M. ; Yahagi, Naohisa ; Nakamura, M. ; Kakushima, N. ; Kodashima, S. ; Ono, S. ; Kobayashi, K. ; Hashimoto, T. ; Yamamichi, N. ; Tateishi, A. ; Shimizu, Y. ; Oka, M. ; Ogura, K. ; Kawabe, T. ; Ichinose, M. ; Omata, M. / Endoscopic submucosal dissection for rectal epithelial neoplasia. In: Endoscopy. 2006 ; Vol. 38, No. 5. pp. 493-497.
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AU - Fujishiro, M.

AU - Yahagi, Naohisa

AU - Nakamura, M.

AU - Kakushima, N.

AU - Kodashima, S.

AU - Ono, S.

AU - Kobayashi, K.

AU - Hashimoto, T.

AU - Yamamichi, N.

AU - Tateishi, A.

AU - Shimizu, Y.

AU - Oka, M.

AU - Ogura, K.

AU - Kawabe, T.

AU - Ichinose, M.

AU - Omata, M.

PY - 2006/5

Y1 - 2006/5

N2 - Background and Study Aims: The technique of endoscopic submucosal dissection (ESD) has recently been developed for enbloc resection of gastric tumors. For oncological reasons and in order to improve the patients' quality of life, it may be desirable to use the same technique for rectal neoplasia. Patients and Methods: Thirty-five consecutive patients with rectal neoplasia who had a preoperative diagnosis of large intraepithelial neoplasias with submucosal fibrosis or located on the rectal folds were enrolled. ESD was carried out with the same technique previously described for the stomach, with some modifications. The efficacy, complications, and follow-up results of the treatment were assessed. Results: The rates of en-bloc resection and en-bloc plus RO resection were 88.6% (31 of 35) and 62.9% (22 of 35), respectively. Hemoglobin levels did not drop by more than 2 g/dl in any of the patients after ESD. None of the patients had to receive blood transfusions or undergo emergency colonoscopy due to bleeding during ESD or hematochezia after ESD. Perforation during ESD occurred in two patients (5.7%), who were managed with conservative medical treatment after endoscopic closure of the perforation. Excluding three patients in whom additional surgery was carried out, all but one of 32 patients were free of recurrence during a mean follow-up period of 36 months (range 12-60 months). The exception was a patient in whom a multiple-piece resection was required; the recurrent (residual) tumor, found 2 months after ESD, was a small adenoma that was again treated endoscopically. Conclusions: ESD is applicable in the rectum with promising results, but the technique is still at a developmental stage and patients should be informed of the potential risks.

AB - Background and Study Aims: The technique of endoscopic submucosal dissection (ESD) has recently been developed for enbloc resection of gastric tumors. For oncological reasons and in order to improve the patients' quality of life, it may be desirable to use the same technique for rectal neoplasia. Patients and Methods: Thirty-five consecutive patients with rectal neoplasia who had a preoperative diagnosis of large intraepithelial neoplasias with submucosal fibrosis or located on the rectal folds were enrolled. ESD was carried out with the same technique previously described for the stomach, with some modifications. The efficacy, complications, and follow-up results of the treatment were assessed. Results: The rates of en-bloc resection and en-bloc plus RO resection were 88.6% (31 of 35) and 62.9% (22 of 35), respectively. Hemoglobin levels did not drop by more than 2 g/dl in any of the patients after ESD. None of the patients had to receive blood transfusions or undergo emergency colonoscopy due to bleeding during ESD or hematochezia after ESD. Perforation during ESD occurred in two patients (5.7%), who were managed with conservative medical treatment after endoscopic closure of the perforation. Excluding three patients in whom additional surgery was carried out, all but one of 32 patients were free of recurrence during a mean follow-up period of 36 months (range 12-60 months). The exception was a patient in whom a multiple-piece resection was required; the recurrent (residual) tumor, found 2 months after ESD, was a small adenoma that was again treated endoscopically. Conclusions: ESD is applicable in the rectum with promising results, but the technique is still at a developmental stage and patients should be informed of the potential risks.

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