Endothelial Cell-Selective Adhesion Molecule Contributes to the Development of Definitive Hematopoiesis in the Fetal Liver

Tomoaki Ueda, Takafumi Yokota, Daisuke Okuzaki, Yoshihiro Uno, Tomoji Mashimo, Yoshiaki Kubota, Takao Sudo, Tomohiko Ishibashi, Yasuhiro Shingai, Yukiko Doi, Takayuki Ozawa, Ritsuko Nakai, Akira Tanimura, Michiko Ichii, Sachiko Ezoe, Hirohiko Shibayama, Kenji Oritani, Yuzuru Kanakura

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Abstract

Ueda et al. shed light on the contribution of endothelial cell-selective adhesion molecule (ESAM) to the ontogeny of definitive hematopoiesis. ESAM deficiency caused high mortality in fetuses after mid-gestation. Expression of Alas2 and adult-type globin genes decreased in ESAM-null HSCs, which resulted in the impairment of development of adult-type erythropoiesis. The authors also revealed functional involvement of ESAM-expressing endothelial cells.

Original languageEnglish
Pages (from-to)992-1005
Number of pages14
JournalStem cell reports
Volume13
Issue number6
DOIs
Publication statusPublished - 2019 Dec 10

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Keywords

  • definitive hematopoiesis
  • endothelial cell-selective adhesion molecule
  • endothelial cells
  • fetal liver
  • hematopoietic stem cells

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

Cite this

Ueda, T., Yokota, T., Okuzaki, D., Uno, Y., Mashimo, T., Kubota, Y., Sudo, T., Ishibashi, T., Shingai, Y., Doi, Y., Ozawa, T., Nakai, R., Tanimura, A., Ichii, M., Ezoe, S., Shibayama, H., Oritani, K., & Kanakura, Y. (2019). Endothelial Cell-Selective Adhesion Molecule Contributes to the Development of Definitive Hematopoiesis in the Fetal Liver. Stem cell reports, 13(6), 992-1005. https://doi.org/10.1016/j.stemcr.2019.11.002