TY - GEN
T1 - Endothelial Chemical Reaction and Drug Test Reproduced on Molded Flexible Collagen Hydrogel Tube
AU - Itai, Shun
AU - Onoe, Hiroaki
N1 - Funding Information:
This work was partly supported by JSPS KAKENHI Grant Number JP YYK0F12, Japan Society for the Promotion of Science (JSPS), Japan, and Fukuzawa Foundation Research Grant, Keio University, Japan.
Publisher Copyright:
© 2021 IEEE.
PY - 2021/6/20
Y1 - 2021/6/20
N2 - We reproduce chemical reactions of blood vessels by a flexibly deformable collagen tube device. The device is composed of an unfixed collagen hydrogel tube, enabling the reproduction of both macro and micro scale deformation of the vessel tissue. In addition, the device is easily perfused because the collagen hydrogel tube is directly attached to silicone tubes. We succeeded in demonstrating the chemical deformation of vessel tissue and endothelial cells by inflammatory mediators. Moreover, the drug testing was presented by anti-inflammatory chemicals. We believe that our flexible culturing device could help the construction of functional blood vessels reproducing in vivo chemical reactions in high similarity, and contribute to biomedical researches and pharmacokinetic testing.
AB - We reproduce chemical reactions of blood vessels by a flexibly deformable collagen tube device. The device is composed of an unfixed collagen hydrogel tube, enabling the reproduction of both macro and micro scale deformation of the vessel tissue. In addition, the device is easily perfused because the collagen hydrogel tube is directly attached to silicone tubes. We succeeded in demonstrating the chemical deformation of vessel tissue and endothelial cells by inflammatory mediators. Moreover, the drug testing was presented by anti-inflammatory chemicals. We believe that our flexible culturing device could help the construction of functional blood vessels reproducing in vivo chemical reactions in high similarity, and contribute to biomedical researches and pharmacokinetic testing.
KW - Collagen
KW - Drug testing
KW - Endothelial cells
KW - In vitro blood vessel
KW - Inflammation
KW - Perfusion
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85114964355&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85114964355&partnerID=8YFLogxK
U2 - 10.1109/Transducers50396.2021.9495658
DO - 10.1109/Transducers50396.2021.9495658
M3 - Conference contribution
AN - SCOPUS:85114964355
T3 - 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
SP - 283
EP - 286
BT - 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
Y2 - 20 June 2021 through 25 June 2021
ER -