@article{8e48b98cb4304bdebc856f0737c87ce0,
title = "Endothelial SIRT-1 has a critical role in the maintenance of capillarization in brown adipose tissue",
abstract = "Brown adipose tissue (BAT) has critical roles in thermogenesis and systemic metabolism. Capillary rarefaction was reported to develop in BAT with dietary obesity, and previous studies showed that suppression of vascular endothelial growth factor A (VEGF-A) reduced capillary density in BAT, promoting the functional decline of this organ. Capillarization is regulated through the balance between angiogenesis and vasculogenesis on the one hand and apoptosis of endothelial cells (ECs) on the other; however, the role of EC apoptosis in BAT remained to be explored. In studies testing the role of boysenberry polyphenols (BoyP) in BAT, we found that BoyP decreased EC apoptosis, enhanced capillarization in BAT, and ameliorated dietary BAT dysfunction, which was associated with the upregulation of nicotinamide adenine dinucleotide-dependent protein deacetylase sirtuin 1 (SIRT-1) in ECs. Our studies suggest that EC SIRT-1 would be one of the potential targets of BoyP that contributes to BAT capillarization and function.",
keywords = "Biological sciences, Cell biology, Molecular biology",
author = "Ryo Furuuchi and Ippei Shimizu and Yohko Yoshida and Goro Katsuumi and Masayoshi Suda and Yoshiaki Kubota and Kenneth Walsh and Tohru Minamino",
note = "Funding Information: We thank Evan Rosen at Harvard Medical School for providing the Ucp-Cre mice. This work was supported by a Grant-in-Aid for Scientific Research (A) ( 20H00533 ) and Grant-in-Aid for Challenging Research (Pioneering) ( 22K18389 ) from MEXT , AMED under Grant Number JP20ek0210114 , and AMED-CREST under Grant Number JP20gm1110012 , and Moonshot Research and Development Program ( 21zf0127003s0201 ), MEXT Supported Program for the Scleroderma Research Foundation at Private Universities Japan , Private University Research Branding Project, and Leading Initiative for Excellent Young Researchers, and grants from the Science Research Promotion Fund, the Takeda Medical Research Foundation , the Vehicle Racing Commemorative Foundation , Ono Medical Research Foundation , and the Suzuken Memorial Foundation (to T.M.), a Grant-in-Aid for Scientific Research (C) ( 19K08485 ; to R.F.), the AMED Project for Elucidating and Controlling Mechanisms of Aging and Longevity under Grant Number JP21gm5010002 , Fusion Oriented REsearch for disruptive Science and Technology under Grant Number JPMJFR200L ( JST FOREST Program; to I.S.), and by a grant from Bourbon Corporation (to T.M., I.S., and Y.Y.). Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = nov,
day = "18",
doi = "10.1016/j.isci.2022.105424",
language = "English",
volume = "25",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "11",
}
