Endothelin-1-induced phosphorylation of the 20-kDa myosin light chain and caldesmon in porcine coronary artery smooth muscle

Yoichiro Abe, Y. Kasuya, M. Kudo, K. Yamashita, K. Goto, T. Masaki, Y. Takuwa

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Endothelin-1 (ET), a potent vasoconstrictor, induces a sustained increase in the phosphorylation level of the 20-kDa myosin light chain (MLC) in porcine coronary artery strips. ET also induces late phosphorylation of caldesmon, which is mimicked by 12-deoxyphorbol 13-isobutyrate, but not by 60 mM KCl. Nitroglycerin, a vasorelaxant, completely reverses the ET-induced phosphorylation of MLC, but not that of caldesmon. These results suggest an important regulatory role of MLC phosphorylation in ET-induced contraction.

Original languageEnglish
Pages (from-to)431-435
Number of pages5
JournalJapanese Journal of Pharmacology
Volume57
Issue number3
Publication statusPublished - 1991
Externally publishedYes

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Calmodulin-Binding Proteins
Myosin Light Chains
Endothelin-1
Smooth Muscle
Coronary Vessels
Swine
Phosphorylation
Nitroglycerin
Vasoconstrictor Agents
Vasodilator Agents

ASJC Scopus subject areas

  • Pharmacology

Cite this

Endothelin-1-induced phosphorylation of the 20-kDa myosin light chain and caldesmon in porcine coronary artery smooth muscle. / Abe, Yoichiro; Kasuya, Y.; Kudo, M.; Yamashita, K.; Goto, K.; Masaki, T.; Takuwa, Y.

In: Japanese Journal of Pharmacology, Vol. 57, No. 3, 1991, p. 431-435.

Research output: Contribution to journalArticle

Abe, Yoichiro ; Kasuya, Y. ; Kudo, M. ; Yamashita, K. ; Goto, K. ; Masaki, T. ; Takuwa, Y. / Endothelin-1-induced phosphorylation of the 20-kDa myosin light chain and caldesmon in porcine coronary artery smooth muscle. In: Japanese Journal of Pharmacology. 1991 ; Vol. 57, No. 3. pp. 431-435.
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AU - Goto, K.

AU - Masaki, T.

AU - Takuwa, Y.

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