Endothelin-l-Induced Phosphorylation of the 20-kDa Myosin Light Chain and Caldesmon in Porcine Coronary Artery Smooth Muscle

Yoichiro Abe, Michiyo Kudo, Kamejiro Yamashita, Yoh Takuwa, Katsutoshi Goto, Tomoh Masaki

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Endothelin-1 (ET), a potent vasoconstrictor, induces a sustained increase in the phosphorylation level of the 20-kDa myosin light chain (MLC) in porcine coronary artery strips. ET also induces late phosphorylation of caldesmon, which is mimicked by 12-deoxyphorbol 13-isobutyrate, but not by 60 mM KC1. Nitroglycerin, a vasorelaxant, completely reverses the ET-induced phosphorylation of MLC, but not that of caldesmon. These results suggest an important regulatory role of MLC phosphorylation in ET-induced contraction.

Original languageEnglish
Pages (from-to)431-435
Number of pages5
JournalThe Japanese Journal of Pharmacology
Issue number3
Publication statusPublished - 1991 Jan
Externally publishedYes


ASJC Scopus subject areas

  • Pharmacology

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