TY - JOUR
T1 - Endothelin-l-Induced Phosphorylation of the 20-kDa Myosin Light Chain and Caldesmon in Porcine Coronary Artery Smooth Muscle
AU - Abe, Yoichiro
AU - Kudo, Michiyo
AU - Yamashita, Kamejiro
AU - Takuwa, Yoh
AU - Goto, Katsutoshi
AU - Masaki, Tomoh
PY - 1991/1
Y1 - 1991/1
N2 - Endothelin-1 (ET), a potent vasoconstrictor, induces a sustained increase in the phosphorylation level of the 20-kDa myosin light chain (MLC) in porcine coronary artery strips. ET also induces late phosphorylation of caldesmon, which is mimicked by 12-deoxyphorbol 13-isobutyrate, but not by 60 mM KC1. Nitroglycerin, a vasorelaxant, completely reverses the ET-induced phosphorylation of MLC, but not that of caldesmon. These results suggest an important regulatory role of MLC phosphorylation in ET-induced contraction.
AB - Endothelin-1 (ET), a potent vasoconstrictor, induces a sustained increase in the phosphorylation level of the 20-kDa myosin light chain (MLC) in porcine coronary artery strips. ET also induces late phosphorylation of caldesmon, which is mimicked by 12-deoxyphorbol 13-isobutyrate, but not by 60 mM KC1. Nitroglycerin, a vasorelaxant, completely reverses the ET-induced phosphorylation of MLC, but not that of caldesmon. These results suggest an important regulatory role of MLC phosphorylation in ET-induced contraction.
UR - http://www.scopus.com/inward/record.url?scp=0026352667&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026352667&partnerID=8YFLogxK
U2 - 10.1254/jjp.57.431
DO - 10.1254/jjp.57.431
M3 - Article
C2 - 1813669
AN - SCOPUS:0026352667
SN - 0021-5198
VL - 57
SP - 431
EP - 435
JO - Japanese Journal of Pharmacology
JF - Japanese Journal of Pharmacology
IS - 3
ER -