Endothelin receptor/physiological role

Y. Abe, Y. Kasuya

Research output: Contribution to journalReview articlepeer-review


Ten years have passed since endothelin (ET) was identified. The physiological roles of ET isopeptide family and its receptor subtypes have been much clarified by means of pharmacological, biochemical and molecular biological approaches. Especially, analyses with ET receptor blockers and approaches with gene-targeting of ET isopeptides and ET receptor subtypes accelerate the pace of investigations into the true physiological and pathophysiological roles of ET system. Here, we introduce the structure of ET receptor subtypes and their intracellular signal transduction. And, we discuss the physiological role of ET receptor subtypes on basis of information obtained from ET receptor-deficient mice.

Original languageEnglish
Pages (from-to)1898-1905
Number of pages8
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number7
Publication statusPublished - 1998 Jul
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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