Engineering cost function for optimizing coherent control between processes with different nonlinearities

J. Chen, Y. Nabekawa, K. Midorikawa, H. Kawano, H. Mizuno, A. Miyawaki, Takasumi Tanabe, F. Kannari

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Multiphoton fluorescence microscopy offers ability of imaging thick samples with enhanced longitudinal resolution, but suffers from issues of photobleaching and phototoxicity. It has been known that three-photon absorption of DNA is one of the causes of phototoxicity. Here, we apply coherent control to enhance the contrast between the two-photon absorption of fluorescent label and the three-photon absorption of biomaterial with engineered cost function, leading to effectively reduced three-photon absorption without loss of valuable two-photon fluorescence.

Original languageEnglish
Title of host publicationInternational Conference on Ultrafast Phenomena, UP 2004
PublisherOptica Publishing Group (formerly OSA)
ISBN (Electronic)9781557528209
Publication statusPublished - 2004
EventInternational Conference on Ultrafast Phenomena, UP 2004 - Niigata, Japan
Duration: 2004 Jul 252004 Jul 30

Publication series

NameOptics InfoBase Conference Papers

Conference

ConferenceInternational Conference on Ultrafast Phenomena, UP 2004
Country/TerritoryJapan
CityNiigata
Period04/7/2504/7/30

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials

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