Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves

Mitsuhiro Terakawa; Shunichi Sato; Daizoh Saitoh; Hitoshi Tsuda; Hiroshi Ashida; Hideyuki Okano; Minoru Obara

doi:10.1117/12.700215

Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves

Mitsuhiro Terakawa, Shunichi Sato, Daizoh Saitoh, Hitoshi Tsuda, Hiroshi Ashida, Hideyuki Okano, Minoru Obara

Department of Physiology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

We delivered a therapeutic gene, hepatocyte growth factor (HGF), to skin grafts of rats using laser-induced stress waves (LISWs) with the objective of enhancing their adhesion. The density and uniformity of neovascularities were enhanced significantly in the grafted skins that were transfected using LISWs, suggesting the efficacy of this method to improve the outcome of skin transplantation.

Original language	English
Title of host publication	Optical Interactions with Tissue and Cells XVIII
DOIs	https://doi.org/10.1117/12.700215
Publication status	Published - 2007 Apr 30
Event	Optical Interactions with Tissue and Cells XVIII - San Jose, CA, United States Duration: 2007 Jan 22 → 2007 Jan 24

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	6435
ISSN (Print)	1605-7422

Other

Other	Optical Interactions with Tissue and Cells XVIII
Country/Territory	United States
City	San Jose, CA
Period	07/1/22 → 07/1/24

Keywords

Gene therapy
Hepatocyte growth factor
Laser-induced stress wave
Nonviral gene transfer
Skin transplantation

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.700215

Cite this

Terakawa, M., Sato, S., Saitoh, D., Tsuda, H., Ashida, H., Okano, H., & Obara, M. (2007). Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves. In Optical Interactions with Tissue and Cells XVIII [643513] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6435). https://doi.org/10.1117/12.700215

Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves. / Terakawa, Mitsuhiro; Sato, Shunichi; Saitoh, Daizoh et al.
Optical Interactions with Tissue and Cells XVIII. 2007. 643513 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6435).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Terakawa, M, Sato, S, Saitoh, D, Tsuda, H, Ashida, H, Okano, H & Obara, M 2007, Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves. in Optical Interactions with Tissue and Cells XVIII., 643513, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6435, Optical Interactions with Tissue and Cells XVIII, San Jose, CA, United States, 07/1/22. https://doi.org/10.1117/12.700215

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abstract = "We delivered a therapeutic gene, hepatocyte growth factor (HGF), to skin grafts of rats using laser-induced stress waves (LISWs) with the objective of enhancing their adhesion. The density and uniformity of neovascularities were enhanced significantly in the grafted skins that were transfected using LISWs, suggesting the efficacy of this method to improve the outcome of skin transplantation.",

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author = "Mitsuhiro Terakawa and Shunichi Sato and Daizoh Saitoh and Hitoshi Tsuda and Hiroshi Ashida and Hideyuki Okano and Minoru Obara",

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AU - Okano, Hideyuki

AU - Obara, Minoru

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AB - We delivered a therapeutic gene, hepatocyte growth factor (HGF), to skin grafts of rats using laser-induced stress waves (LISWs) with the objective of enhancing their adhesion. The density and uniformity of neovascularities were enhanced significantly in the grafted skins that were transfected using LISWs, suggesting the efficacy of this method to improve the outcome of skin transplantation.

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Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves

Abstract

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Keywords

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