Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves

Mitsuhiro Terakawa, Shunichi Sato, Daizoh Saitoh, Hitoshi Tsuda, Hiroshi Ashida, Hideyuki Okano, Minoru Obara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We delivered a therapeutic gene, hepatocyte growth factor (HGF), to skin grafts of rats using laser-induced stress waves (LISWs) with the objective of enhancing their adhesion. The density and uniformity of neovascularities were enhanced significantly in the grafted skins that were transfected using LISWs, suggesting the efficacy of this method to improve the outcome of skin transplantation.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6435
DOIs
Publication statusPublished - 2007
EventOptical Interactions with Tissue and Cells XVIII - San Jose, CA, United States
Duration: 2007 Jan 222007 Jan 24

Other

OtherOptical Interactions with Tissue and Cells XVIII
CountryUnited States
CitySan Jose, CA
Period07/1/2207/1/24

Fingerprint

Gene transfer
Skin
Lasers
Grafts
Rats
Adhesion
Genes
Intercellular Signaling Peptides and Proteins
Hepatocytes

Keywords

  • Gene therapy
  • Hepatocyte growth factor
  • Laser-induced stress wave
  • Nonviral gene transfer
  • Skin transplantation

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Terakawa, M., Sato, S., Saitoh, D., Tsuda, H., Ashida, H., Okano, H., & Obara, M. (2007). Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 6435). [643513] https://doi.org/10.1117/12.700215

Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves. / Terakawa, Mitsuhiro; Sato, Shunichi; Saitoh, Daizoh; Tsuda, Hitoshi; Ashida, Hiroshi; Okano, Hideyuki; Obara, Minoru.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6435 2007. 643513.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Terakawa, M, Sato, S, Saitoh, D, Tsuda, H, Ashida, H, Okano, H & Obara, M 2007, Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 6435, 643513, Optical Interactions with Tissue and Cells XVIII, San Jose, CA, United States, 07/1/22. https://doi.org/10.1117/12.700215
Terakawa M, Sato S, Saitoh D, Tsuda H, Ashida H, Okano H et al. Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6435. 2007. 643513 https://doi.org/10.1117/12.700215
Terakawa, Mitsuhiro ; Sato, Shunichi ; Saitoh, Daizoh ; Tsuda, Hitoshi ; Ashida, Hiroshi ; Okano, Hideyuki ; Obara, Minoru. / Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6435 2007.
@inproceedings{3f4752dab4a9414494786494c202188c,
title = "Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves",
abstract = "We delivered a therapeutic gene, hepatocyte growth factor (HGF), to skin grafts of rats using laser-induced stress waves (LISWs) with the objective of enhancing their adhesion. The density and uniformity of neovascularities were enhanced significantly in the grafted skins that were transfected using LISWs, suggesting the efficacy of this method to improve the outcome of skin transplantation.",
keywords = "Gene therapy, Hepatocyte growth factor, Laser-induced stress wave, Nonviral gene transfer, Skin transplantation",
author = "Mitsuhiro Terakawa and Shunichi Sato and Daizoh Saitoh and Hitoshi Tsuda and Hiroshi Ashida and Hideyuki Okano and Minoru Obara",
year = "2007",
doi = "10.1117/12.700215",
language = "English",
isbn = "0819465488",
volume = "6435",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves

AU - Terakawa, Mitsuhiro

AU - Sato, Shunichi

AU - Saitoh, Daizoh

AU - Tsuda, Hitoshi

AU - Ashida, Hiroshi

AU - Okano, Hideyuki

AU - Obara, Minoru

PY - 2007

Y1 - 2007

N2 - We delivered a therapeutic gene, hepatocyte growth factor (HGF), to skin grafts of rats using laser-induced stress waves (LISWs) with the objective of enhancing their adhesion. The density and uniformity of neovascularities were enhanced significantly in the grafted skins that were transfected using LISWs, suggesting the efficacy of this method to improve the outcome of skin transplantation.

AB - We delivered a therapeutic gene, hepatocyte growth factor (HGF), to skin grafts of rats using laser-induced stress waves (LISWs) with the objective of enhancing their adhesion. The density and uniformity of neovascularities were enhanced significantly in the grafted skins that were transfected using LISWs, suggesting the efficacy of this method to improve the outcome of skin transplantation.

KW - Gene therapy

KW - Hepatocyte growth factor

KW - Laser-induced stress wave

KW - Nonviral gene transfer

KW - Skin transplantation

UR - http://www.scopus.com/inward/record.url?scp=34247324430&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247324430&partnerID=8YFLogxK

U2 - 10.1117/12.700215

DO - 10.1117/12.700215

M3 - Conference contribution

AN - SCOPUS:34247324430

SN - 0819465488

SN - 9780819465481

VL - 6435

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -