Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves

Mitsuhiro Terakawa, Shunichi Sato, Daizoh Saitoh, Hitoshi Tsuda, Hiroshi Ashida, Hideyuki Okano, Minoru Obara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We delivered a therapeutic gene, hepatocyte growth factor (HGF), to skin grafts of rats using laser-induced stress waves (LISWs) with the objective of enhancing their adhesion. The density and uniformity of neovascularities were enhanced significantly in the grafted skins that were transfected using LISWs, suggesting the efficacy of this method to improve the outcome of skin transplantation.

Original languageEnglish
Title of host publicationOptical Interactions with Tissue and Cells XVIII
DOIs
Publication statusPublished - 2007 Apr 30
EventOptical Interactions with Tissue and Cells XVIII - San Jose, CA, United States
Duration: 2007 Jan 222007 Jan 24

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6435
ISSN (Print)1605-7422

Other

OtherOptical Interactions with Tissue and Cells XVIII
CountryUnited States
CitySan Jose, CA
Period07/1/2207/1/24

Keywords

  • Gene therapy
  • Hepatocyte growth factor
  • Laser-induced stress wave
  • Nonviral gene transfer
  • Skin transplantation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Terakawa, M., Sato, S., Saitoh, D., Tsuda, H., Ashida, H., Okano, H., & Obara, M. (2007). Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves. In Optical Interactions with Tissue and Cells XVIII [643513] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6435). https://doi.org/10.1117/12.700215