Abstract
Endoscopic diode laser ablation using indocyanine green (ICG) was performed to the canine stomach to assess the safety and efficacy for the treatment of early gastric cancer. Approximately 8 ml of ICG solution with the concentration of 1 mg/ml was administrated to the submucosal layer so that the mucosal surface was elevated within the limits of 4 cm in diameter. Twenty five watts non-contact with 3 mm bean spot diameter was irradiated to the gastric wall by the 1 second pulse mode. With this irradiated condition, 4 or 5 repeat irradiation could remove the mucosal layer without carbonization. The ICG containing submucosal layer was efficiently ablated even with laser output of 5W. By observing the color tone of the irradiated surface, we could judge the ablation depth. Histological examination revealed the submucosal layer was almost eliminated when the irradiated surface presented light green or yellowish green. In this case the muscularis propriae was not damaged because the ICG solution blocked the direct laser penetration. Six days after irradiation, endoscopic examination and histological examination showed satisfactory healing process. We think this combination therapy using diode laser irradiation and the ICG solution injection into the submucosal layer would be useful for early gastric cancer with/without the submucosal invasion, especially in inoperable cases.
| Original language | English |
|---|---|
| Pages (from-to) | 1766-1774 |
| Number of pages | 9 |
| Journal | Gastroenterological Endoscopy |
| Volume | 39 |
| Issue number | 10 |
| Publication status | Published - 1997 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Gastroenterology
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Enhanced diode laser ablation using submucosal injection of indocyanine green solution; Part II; - Endoscopic irradiation to the canine stomach. / Hayashi, T.; Arai, Tsunenori; Hino, S.; Tajiri, H.; Kuroki, M.; Shitaya, M.; Aono, S.; Kobayashi, M.; Nagao, S.; Miyahara, T.; Hino, K.; Masuda, K.; Suzuki, H.; Kikuchi, M.; Niwa, H.
In: Gastroenterological Endoscopy, Vol. 39, No. 10, 1997, p. 1766-1774.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enhanced diode laser ablation using submucosal injection of indocyanine green solution; Part II; - Endoscopic irradiation to the canine stomach
AU - Hayashi, T.
AU - Arai, Tsunenori
AU - Hino, S.
AU - Tajiri, H.
AU - Kuroki, M.
AU - Shitaya, M.
AU - Aono, S.
AU - Kobayashi, M.
AU - Nagao, S.
AU - Miyahara, T.
AU - Hino, K.
AU - Masuda, K.
AU - Suzuki, H.
AU - Kikuchi, M.
AU - Niwa, H.
PY - 1997
Y1 - 1997
N2 - Endoscopic diode laser ablation using indocyanine green (ICG) was performed to the canine stomach to assess the safety and efficacy for the treatment of early gastric cancer. Approximately 8 ml of ICG solution with the concentration of 1 mg/ml was administrated to the submucosal layer so that the mucosal surface was elevated within the limits of 4 cm in diameter. Twenty five watts non-contact with 3 mm bean spot diameter was irradiated to the gastric wall by the 1 second pulse mode. With this irradiated condition, 4 or 5 repeat irradiation could remove the mucosal layer without carbonization. The ICG containing submucosal layer was efficiently ablated even with laser output of 5W. By observing the color tone of the irradiated surface, we could judge the ablation depth. Histological examination revealed the submucosal layer was almost eliminated when the irradiated surface presented light green or yellowish green. In this case the muscularis propriae was not damaged because the ICG solution blocked the direct laser penetration. Six days after irradiation, endoscopic examination and histological examination showed satisfactory healing process. We think this combination therapy using diode laser irradiation and the ICG solution injection into the submucosal layer would be useful for early gastric cancer with/without the submucosal invasion, especially in inoperable cases.
AB - Endoscopic diode laser ablation using indocyanine green (ICG) was performed to the canine stomach to assess the safety and efficacy for the treatment of early gastric cancer. Approximately 8 ml of ICG solution with the concentration of 1 mg/ml was administrated to the submucosal layer so that the mucosal surface was elevated within the limits of 4 cm in diameter. Twenty five watts non-contact with 3 mm bean spot diameter was irradiated to the gastric wall by the 1 second pulse mode. With this irradiated condition, 4 or 5 repeat irradiation could remove the mucosal layer without carbonization. The ICG containing submucosal layer was efficiently ablated even with laser output of 5W. By observing the color tone of the irradiated surface, we could judge the ablation depth. Histological examination revealed the submucosal layer was almost eliminated when the irradiated surface presented light green or yellowish green. In this case the muscularis propriae was not damaged because the ICG solution blocked the direct laser penetration. Six days after irradiation, endoscopic examination and histological examination showed satisfactory healing process. We think this combination therapy using diode laser irradiation and the ICG solution injection into the submucosal layer would be useful for early gastric cancer with/without the submucosal invasion, especially in inoperable cases.
UR - http://www.scopus.com/inward/record.url?scp=0030787140&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030787140&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0030787140
VL - 39
SP - 1766
EP - 1774
JO - Gastroenterological Endoscopy
JF - Gastroenterological Endoscopy
SN - 0387-1207
IS - 10
ER -