Enhanced Functional Recovery from Spinal Cord Injury in Aged Mice after Stem Cell Transplantation through HGF Induction

Morito Takano, Soya Kawabata, Shinsuke Shibata, Akimasa Yasuda, Satoshi Nori, Osahiko Tsuji, Narihito Nagoshi, Akio Iwanami, Hayao Ebise, Keisuke Horiuchi, Hideyuki Okano, Masaya Nakamura

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The number of elderly patients with spinal cord injury (SCI) is increasing worldwide, representing a serious burden for both the affected patients and the community. Previous studies have demonstrated that neural stem cell (NSC) transplantation is an effective treatment for SCI in young animals. Here we show that NSC transplantation is as effective in aged mice as it is in young mice, even though aged mice exhibit more severe neurological deficits after SCI. NSCs grafted into aged mice exhibited better survival than those grafted into young mice. Furthermore, we show that the neurotrophic factor HGF plays a key role in the enhanced functional recovery after NSC transplantation observed in aged mice with SCI. The unexpected results of the present study suggest that NSC transplantation is a potential therapeutic modality for SCI, even in elderly patients. In this article, Nakamura, Okano, and colleagues report that NSC transplantation therapy is as effective in aged mice as it is in young mice, despite the more severe damage after SCI in aged mice. HGF is a key factor in the enhanced functional recovery after NSC transplantation observed in aged mice with SCI.

Original languageEnglish
JournalStem Cell Reports
DOIs
Publication statusAccepted/In press - 2016 Dec 11

Fingerprint

Stem Cell Transplantation
Stem cells
Spinal Cord Injuries
Neural Stem Cells
Recovery
Nerve Growth Factors
Animals
Cell- and Tissue-Based Therapy
Survival

Keywords

  • Aging
  • Neural stem cell transplantation
  • Spinal cord injury

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

Cite this

Enhanced Functional Recovery from Spinal Cord Injury in Aged Mice after Stem Cell Transplantation through HGF Induction. / Takano, Morito; Kawabata, Soya; Shibata, Shinsuke; Yasuda, Akimasa; Nori, Satoshi; Tsuji, Osahiko; Nagoshi, Narihito; Iwanami, Akio; Ebise, Hayao; Horiuchi, Keisuke; Okano, Hideyuki; Nakamura, Masaya.

In: Stem Cell Reports, 11.12.2016.

Research output: Contribution to journalArticle

Takano, Morito ; Kawabata, Soya ; Shibata, Shinsuke ; Yasuda, Akimasa ; Nori, Satoshi ; Tsuji, Osahiko ; Nagoshi, Narihito ; Iwanami, Akio ; Ebise, Hayao ; Horiuchi, Keisuke ; Okano, Hideyuki ; Nakamura, Masaya. / Enhanced Functional Recovery from Spinal Cord Injury in Aged Mice after Stem Cell Transplantation through HGF Induction. In: Stem Cell Reports. 2016.
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