The number of elderly patients with spinal cord injury (SCI) is increasing worldwide, representing a serious burden for both the affected patients and the community. Previous studies have demonstrated that neural stem cell (NSC) transplantation is an effective treatment for SCI in young animals. Here we show that NSC transplantation is as effective in aged mice as it is in young mice, even though aged mice exhibit more severe neurological deficits after SCI. NSCs grafted into aged mice exhibited better survival than those grafted into young mice. Furthermore, we show that the neurotrophic factor HGF plays a key role in the enhanced functional recovery after NSC transplantation observed in aged mice with SCI. The unexpected results of the present study suggest that NSC transplantation is a potential therapeutic modality for SCI, even in elderly patients. In this article, Nakamura, Okano, and colleagues report that NSC transplantation therapy is as effective in aged mice as it is in young mice, despite the more severe damage after SCI in aged mice. HGF is a key factor in the enhanced functional recovery after NSC transplantation observed in aged mice with SCI.
- Neural stem cell transplantation
- Spinal cord injury
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology