Enhanced neurogenesis in the ischemic striatum following EGF-induced expansion of transit-amplifying cells in the subventricular zone

Mikiko Ninomiya, Toru Yamashita, Nobuo Araki, Hideyuki Okano, Kazunobu Sawamoto

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

In the subventricular zone (SVZ) of the adult mammalian brain, neural stem cells continually produce transit-amplifying precursors, which generate neuroblasts migrating into the olfactory bulb. Previous studies have suggested that SVZ cells also have the capacity to generate some striatal neurons after cerebral ischemia. The infusion of epidermal growth factor (EGF) has been demonstrated to increase the number of these regenerated neurons. However, which cell types in the SVZ are stimulated to proliferate or differentiate after EGF infusion remains unknown. In this paper, we demonstrated that cerebral ischemia results in an increase in the number of EGF receptor (EGFR)-positive transit-amplifying cells in the SVZ. EGF infusion into the ischemic brain caused the number of transit-amplifying cells to increase and the number of neuroblasts to decrease. On the other hand, after an interval of 6 days after the discontinuation of EGF infusion, a significant increase in the number of neuroblasts was found, both in the striatum and the SVZ. These results suggest that the replacement of neurons in injured striatum can be enhanced by an EGF-induced expansion of transit-amplifying cells in the SVZ.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalNeuroscience Letters
Volume403
Issue number1-2
DOIs
Publication statusPublished - 2006 Jul 31

Fingerprint

Lateral Ventricles
Neurogenesis
Epidermal Growth Factor
Brain Ischemia
Neurons
Corpus Striatum
Neural Stem Cells
Olfactory Bulb
Epidermal Growth Factor Receptor
Brain Stem
Brain

Keywords

  • Cerebral ischemia
  • EGF
  • Neurogenesis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Enhanced neurogenesis in the ischemic striatum following EGF-induced expansion of transit-amplifying cells in the subventricular zone. / Ninomiya, Mikiko; Yamashita, Toru; Araki, Nobuo; Okano, Hideyuki; Sawamoto, Kazunobu.

In: Neuroscience Letters, Vol. 403, No. 1-2, 31.07.2006, p. 63-67.

Research output: Contribution to journalArticle

Ninomiya, Mikiko ; Yamashita, Toru ; Araki, Nobuo ; Okano, Hideyuki ; Sawamoto, Kazunobu. / Enhanced neurogenesis in the ischemic striatum following EGF-induced expansion of transit-amplifying cells in the subventricular zone. In: Neuroscience Letters. 2006 ; Vol. 403, No. 1-2. pp. 63-67.
@article{93611888f6554ab8818774cd396ba14f,
title = "Enhanced neurogenesis in the ischemic striatum following EGF-induced expansion of transit-amplifying cells in the subventricular zone",
abstract = "In the subventricular zone (SVZ) of the adult mammalian brain, neural stem cells continually produce transit-amplifying precursors, which generate neuroblasts migrating into the olfactory bulb. Previous studies have suggested that SVZ cells also have the capacity to generate some striatal neurons after cerebral ischemia. The infusion of epidermal growth factor (EGF) has been demonstrated to increase the number of these regenerated neurons. However, which cell types in the SVZ are stimulated to proliferate or differentiate after EGF infusion remains unknown. In this paper, we demonstrated that cerebral ischemia results in an increase in the number of EGF receptor (EGFR)-positive transit-amplifying cells in the SVZ. EGF infusion into the ischemic brain caused the number of transit-amplifying cells to increase and the number of neuroblasts to decrease. On the other hand, after an interval of 6 days after the discontinuation of EGF infusion, a significant increase in the number of neuroblasts was found, both in the striatum and the SVZ. These results suggest that the replacement of neurons in injured striatum can be enhanced by an EGF-induced expansion of transit-amplifying cells in the SVZ.",
keywords = "Cerebral ischemia, EGF, Neurogenesis",
author = "Mikiko Ninomiya and Toru Yamashita and Nobuo Araki and Hideyuki Okano and Kazunobu Sawamoto",
year = "2006",
month = "7",
day = "31",
doi = "10.1016/j.neulet.2006.04.039",
language = "English",
volume = "403",
pages = "63--67",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - Enhanced neurogenesis in the ischemic striatum following EGF-induced expansion of transit-amplifying cells in the subventricular zone

AU - Ninomiya, Mikiko

AU - Yamashita, Toru

AU - Araki, Nobuo

AU - Okano, Hideyuki

AU - Sawamoto, Kazunobu

PY - 2006/7/31

Y1 - 2006/7/31

N2 - In the subventricular zone (SVZ) of the adult mammalian brain, neural stem cells continually produce transit-amplifying precursors, which generate neuroblasts migrating into the olfactory bulb. Previous studies have suggested that SVZ cells also have the capacity to generate some striatal neurons after cerebral ischemia. The infusion of epidermal growth factor (EGF) has been demonstrated to increase the number of these regenerated neurons. However, which cell types in the SVZ are stimulated to proliferate or differentiate after EGF infusion remains unknown. In this paper, we demonstrated that cerebral ischemia results in an increase in the number of EGF receptor (EGFR)-positive transit-amplifying cells in the SVZ. EGF infusion into the ischemic brain caused the number of transit-amplifying cells to increase and the number of neuroblasts to decrease. On the other hand, after an interval of 6 days after the discontinuation of EGF infusion, a significant increase in the number of neuroblasts was found, both in the striatum and the SVZ. These results suggest that the replacement of neurons in injured striatum can be enhanced by an EGF-induced expansion of transit-amplifying cells in the SVZ.

AB - In the subventricular zone (SVZ) of the adult mammalian brain, neural stem cells continually produce transit-amplifying precursors, which generate neuroblasts migrating into the olfactory bulb. Previous studies have suggested that SVZ cells also have the capacity to generate some striatal neurons after cerebral ischemia. The infusion of epidermal growth factor (EGF) has been demonstrated to increase the number of these regenerated neurons. However, which cell types in the SVZ are stimulated to proliferate or differentiate after EGF infusion remains unknown. In this paper, we demonstrated that cerebral ischemia results in an increase in the number of EGF receptor (EGFR)-positive transit-amplifying cells in the SVZ. EGF infusion into the ischemic brain caused the number of transit-amplifying cells to increase and the number of neuroblasts to decrease. On the other hand, after an interval of 6 days after the discontinuation of EGF infusion, a significant increase in the number of neuroblasts was found, both in the striatum and the SVZ. These results suggest that the replacement of neurons in injured striatum can be enhanced by an EGF-induced expansion of transit-amplifying cells in the SVZ.

KW - Cerebral ischemia

KW - EGF

KW - Neurogenesis

UR - http://www.scopus.com/inward/record.url?scp=33745504597&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745504597&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2006.04.039

DO - 10.1016/j.neulet.2006.04.039

M3 - Article

VL - 403

SP - 63

EP - 67

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -