Enhanced photodynamic effect by the assistance of nanosecond-pulsed-laser- induced stress wave

Mitsuhiro Terakawa, Shunichi Sato, Satoko Kawauchi, Hiroshi Ashida, Minoru Obara

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Abstract

We demonstrated that phototoxicity was enhanced by applying a single nanosecond-pulsed-laser-induced stress wave (LISW) to cultured cells before photodynamic treatment. Observation with a confocal laser scanning microscope showed that the enhanced phototoxicity is attributable to the larger cellular uptake of a photosensitizer due to the effect of LISW. It was also confirmed that the application of LISW alone did not reduce the cell viability.

Original languageEnglish
Pages (from-to)L877-L878
JournalJapanese Journal of Applied Physics, Part 2: Letters
Volume43
Issue number7 A
DOIs
Publication statusPublished - 2004 Jul 1

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Keywords

  • Drug delivery
  • Laser-induced stress wave
  • Photodynamic therapy
  • Photofrin II
  • Photosensitizer
  • Plasma membrane
  • Targeting

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy (miscellaneous)
  • Physics and Astronomy(all)

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