Enhanced photodynamic effect by the assistance of nanosecond-pulsed-laser- induced stress wave

Mitsuhiro Terakawa, Shunichi Sato, Satoko Kawauchi, Hiroshi Ashida, Minoru Obara

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We demonstrated that phototoxicity was enhanced by applying a single nanosecond-pulsed-laser-induced stress wave (LISW) to cultured cells before photodynamic treatment. Observation with a confocal laser scanning microscope showed that the enhanced phototoxicity is attributable to the larger cellular uptake of a photosensitizer due to the effect of LISW. It was also confirmed that the application of LISW alone did not reduce the cell viability.

Original languageEnglish
JournalJapanese Journal of Applied Physics, Part 2: Letters
Volume43
Issue number7 A
DOIs
Publication statusPublished - 2004 Jul 1

Fingerprint

stress waves
Pulsed lasers
pulsed lasers
Lasers
Cells
lasers
Photosensitizers
cultured cells
viability
Microscopes
microscopes
Scanning
scanning

Keywords

  • Drug delivery
  • Laser-induced stress wave
  • Photodynamic therapy
  • Photofrin II
  • Photosensitizer
  • Plasma membrane
  • Targeting

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

Enhanced photodynamic effect by the assistance of nanosecond-pulsed-laser- induced stress wave. / Terakawa, Mitsuhiro; Sato, Shunichi; Kawauchi, Satoko; Ashida, Hiroshi; Obara, Minoru.

In: Japanese Journal of Applied Physics, Part 2: Letters, Vol. 43, No. 7 A, 01.07.2004.

Research output: Contribution to journalArticle

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