Enhanced photodynamic effect by the assistance of nanosecond-pulsed-laser- induced stress wave

Mitsuhiro Terakawa, Shunichi Sato, Satoko Kawauchi, Hiroshi Ashida, Minoru Obara

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    We demonstrated that phototoxicity was enhanced by applying a single nanosecond-pulsed-laser-induced stress wave (LISW) to cultured cells before photodynamic treatment. Observation with a confocal laser scanning microscope showed that the enhanced phototoxicity is attributable to the larger cellular uptake of a photosensitizer due to the effect of LISW. It was also confirmed that the application of LISW alone did not reduce the cell viability.

    Original languageEnglish
    Pages (from-to)L877-L878
    JournalJapanese Journal of Applied Physics, Part 2: Letters
    Volume43
    Issue number7 A
    DOIs
    Publication statusPublished - 2004 Jul 1

    Keywords

    • Drug delivery
    • Laser-induced stress wave
    • Photodynamic therapy
    • Photofrin II
    • Photosensitizer
    • Plasma membrane
    • Targeting

    ASJC Scopus subject areas

    • Engineering(all)
    • Physics and Astronomy (miscellaneous)
    • Physics and Astronomy(all)

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