Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes

Tatsuhiro Masaoka; Hidekazu Suzuki; Hiroshi Hosoda; Takayuki Ota; Yuriko Minegishi; Hiroshi Nagata; Kenji Kangawa; Hiromasa Ishii

doi:10.1016/S0014-5793(03)00306-5

Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes

Tatsuhiro Masaoka, Hidekazu Suzuki, Hiroshi Hosoda, Takayuki Ota, Yuriko Minegishi, Hiroshi Nagata, Kenji Kangawa, Hiromasa Ishii

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Abstract

Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.

Original language	English
Pages (from-to)	64-68
Number of pages	5
Journal	FEBS Letters
Volume	541
Issue number	1-3
DOIs	https://doi.org/10.1016/S0014-5793(03)00306-5
Publication status	Published - 2003 Apr 24
Externally published	Yes

Keywords

Diabetes
Ghrelin
Growth hormone
Preproghrelin
Stomach

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0014-5793(03)00306-5

Cite this

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title = "Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes",

abstract = "Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.",

keywords = "Diabetes, Ghrelin, Growth hormone, Preproghrelin, Stomach",

author = "Tatsuhiro Masaoka and Hidekazu Suzuki and Hiroshi Hosoda and Takayuki Ota and Yuriko Minegishi and Hiroshi Nagata and Kenji Kangawa and Hiromasa Ishii",

note = "Funding Information: This study was supported by a Grant-in-Aid for Scientific Research C (No. 13670555: to H.S.) from the Japan Society for the Promotion of Science (JSPS) and by a Keio Gijyuku Academic Development Fund. The authors thank Dr. Sachiko Nomura and Miss Kumiko Kurabayashi, Center for Integrated Medical Research, School of Medicine, Keio University, for their technical assistance.",

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doi = "10.1016/S0014-5793(03)00306-5",

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pages = "64--68",

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T1 - Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes

AU - Masaoka, Tatsuhiro

AU - Suzuki, Hidekazu

AU - Hosoda, Hiroshi

AU - Ota, Takayuki

AU - Minegishi, Yuriko

AU - Nagata, Hiroshi

AU - Kangawa, Kenji

AU - Ishii, Hiromasa

N1 - Funding Information: This study was supported by a Grant-in-Aid for Scientific Research C (No. 13670555: to H.S.) from the Japan Society for the Promotion of Science (JSPS) and by a Keio Gijyuku Academic Development Fund. The authors thank Dr. Sachiko Nomura and Miss Kumiko Kurabayashi, Center for Integrated Medical Research, School of Medicine, Keio University, for their technical assistance.

PY - 2003/4/24

Y1 - 2003/4/24

N2 - Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.

AB - Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.

KW - Diabetes

KW - Ghrelin

KW - Growth hormone

KW - Preproghrelin

KW - Stomach

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SN - 0014-5793

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JO - FEBS Letters

JF - FEBS Letters

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ER -

Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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