Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes

Tatsuhiro Masaoka, Hidekazu Suzuki, Hiroshi Hosoda, Takayuki Ota, Yuriko Minegishi, Hiroshi Nagata, Kenji Kangawa, Hiromasa Ishii

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.

Original languageEnglish
Pages (from-to)64-68
Number of pages5
JournalFEBS Letters
Volume541
Issue number1-3
DOIs
Publication statusPublished - 2003 Apr 24

Keywords

  • Diabetes
  • Ghrelin
  • Growth hormone
  • Preproghrelin
  • Stomach

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Masaoka, T., Suzuki, H., Hosoda, H., Ota, T., Minegishi, Y., Nagata, H., Kangawa, K., & Ishii, H. (2003). Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes. FEBS Letters, 541(1-3), 64-68. https://doi.org/10.1016/S0014-5793(03)00306-5