Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under

Junko Kizu; Motoki Arakawa; Yoshihiro Arakawa; Fusako Komoda; Masaru Takamizawa; Tsutomu Iwata; Tetsuo Hayakawa; Kazuhiro Imai

doi:10.1002/(SICI)1099-0801(199911)13:7<462::AID-BMC912>3.0.CO;2-P

Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under

Junko Kizu, Motoki Arakawa, Yoshihiro Arakawa, Fusako Komoda, Masaru Takamizawa, Tsutomu Iwata, Tetsuo Hayakawa, Kazuhiro Imai

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The plasma levels of theophylline (TP) and its metabolites were measured in patients with bronchial asthma who were treated with a slow-release preparation of TP. The ratios of the plasma levels of these metabolites to TP levels in the group aged 1-4 years were larger than those in the group aged 5 years and older, suggesting enhanced activity of drug-metabolizing enzymes during infancy.

Original language	English
Pages (from-to)	462-464
Number of pages	3
Journal	Biomedical Chromatography
Volume	13
Issue number	7
DOIs	https://doi.org/10.1002/(SICI)1099-0801(199911)13:7<462::AID-BMC912>3.0.CO;2-P
Publication status	Published - 1999

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1002/(SICI)1099-0801(199911)13:7<462::AID-BMC912>3.0.CO;2-P

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abstract = "The plasma levels of theophylline (TP) and its metabolites were measured in patients with bronchial asthma who were treated with a slow-release preparation of TP. The ratios of the plasma levels of these metabolites to TP levels in the group aged 1-4 years were larger than those in the group aged 5 years and older, suggesting enhanced activity of drug-metabolizing enzymes during infancy.",

author = "Junko Kizu and Motoki Arakawa and Yoshihiro Arakawa and Fusako Komoda and Masaru Takamizawa and Tsutomu Iwata and Tetsuo Hayakawa and Kazuhiro Imai",

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AU - Kizu, Junko

AU - Arakawa, Motoki

AU - Arakawa, Yoshihiro

AU - Komoda, Fusako

AU - Takamizawa, Masaru

AU - Iwata, Tsutomu

AU - Hayakawa, Tetsuo

AU - Imai, Kazuhiro

PY - 1999

Y1 - 1999

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AB - The plasma levels of theophylline (TP) and its metabolites were measured in patients with bronchial asthma who were treated with a slow-release preparation of TP. The ratios of the plasma levels of these metabolites to TP levels in the group aged 1-4 years were larger than those in the group aged 5 years and older, suggesting enhanced activity of drug-metabolizing enzymes during infancy.

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ER -

Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under

Abstract

ASJC Scopus subject areas

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