Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under

Junko Kizu, Motoki Arakawa, Yoshihiro Arakawa, Fusako Komoda, Masaru Takamizawa, Tsutomu Iwata, Tetsuo Hayakawa, Kazuhiro Imai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The plasma levels of theophylline (TP) and its metabolites were measured in patients with bronchial asthma who were treated with a slow-release preparation of TP. The ratios of the plasma levels of these metabolites to TP levels in the group aged 1-4 years were larger than those in the group aged 5 years and older, suggesting enhanced activity of drug-metabolizing enzymes during infancy.

Original languageEnglish
Pages (from-to)462-464
Number of pages3
JournalBiomedical Chromatography
Volume13
Issue number7
DOIs
Publication statusPublished - 1999
Externally publishedYes

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Theophylline
Metabolism
Asthma
Metabolites
Plasmas
Enzymes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Pharmacology

Cite this

Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under. / Kizu, Junko; Arakawa, Motoki; Arakawa, Yoshihiro; Komoda, Fusako; Takamizawa, Masaru; Iwata, Tsutomu; Hayakawa, Tetsuo; Imai, Kazuhiro.

In: Biomedical Chromatography, Vol. 13, No. 7, 1999, p. 462-464.

Research output: Contribution to journalArticle

Kizu, J, Arakawa, M, Arakawa, Y, Komoda, F, Takamizawa, M, Iwata, T, Hayakawa, T & Imai, K 1999, 'Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under', Biomedical Chromatography, vol. 13, no. 7, pp. 462-464. https://doi.org/10.1002/(SICI)1099-0801(199911)13:7<462::AID-BMC912>3.0.CO;2-P
Kizu, Junko ; Arakawa, Motoki ; Arakawa, Yoshihiro ; Komoda, Fusako ; Takamizawa, Masaru ; Iwata, Tsutomu ; Hayakawa, Tetsuo ; Imai, Kazuhiro. / Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under. In: Biomedical Chromatography. 1999 ; Vol. 13, No. 7. pp. 462-464.
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