Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under

Junko Kizu, Motoki Arakawa, Yoshihiro Arakawa, Fusako Komoda, Masaru Takamizawa, Tsutomu Iwata, Tetsuo Hayakawa, Kazuhiro Imai

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Abstract

The plasma levels of theophylline (TP) and its metabolites were measured in patients with bronchial asthma who were treated with a slow-release preparation of TP. The ratios of the plasma levels of these metabolites to TP levels in the group aged 1-4 years were larger than those in the group aged 5 years and older, suggesting enhanced activity of drug-metabolizing enzymes during infancy.

Original languageEnglish
Pages (from-to)462-464
Number of pages3
JournalBiomedical Chromatography
Volume13
Issue number7
DOIs
Publication statusPublished - 1999 Nov 24

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Kizu, J., Arakawa, M., Arakawa, Y., Komoda, F., Takamizawa, M., Iwata, T., Hayakawa, T., & Imai, K. (1999). Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under. Biomedical Chromatography, 13(7), 462-464. https://doi.org/10.1002/(SICI)1099-0801(199911)13:7<462::AID-BMC912>3.0.CO;2-P