Enhancement of CDP-DG:inositol transferase activity in src- and erbB2- transformed cells

Masaya Imoto, Yoshiko Taniguchi, Hiroaki Fujiwara, Kazuo Umezawa

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Phosphatidylinositol (PI) synthesis was activated in Rous sarcoma virus- infected NIH3T3 or activated erbB2-transformed NIH3T3 cells. The in vitro activity of CDP-DG:inositol transferase prepared from these cells was also higher than that from normal parent NIH3T3 cells, although phospholipase C and PI kinase activities were not significantly different among these cells. A tyrosine kinase inhibitor, erbstatin, inhibited the PI synthesis in cultured cells, suggesting that Src and ErbB2-associated tyrosine kinases are involved in activation of CDP-DG:inositol transferase in these cell lines.

Original languageEnglish
Pages (from-to)151-154
Number of pages4
JournalExperimental Cell Research
Issue number1
Publication statusPublished - 1994 Jan 1


ASJC Scopus subject areas

  • Cell Biology

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