Enhancing effect by heparin on shear-induced platelet aggregation

K. Kawano, Y. Ikeda, M. Handa, Tetsuji Kamata, H. Anbo, Y. Araki, Y. Kawai, K. Watanabe, I. Itagaki, K. Kawakami, M. Fukuyama, K. Sakai

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Abstract

We have recently developed a new device for continuously measuring SIPA. Using the device, we have investigated the effects of heparin on SIPA. Heparin itself enhanced SIPA in the absence of agonists in a dose-dependent manner, whereas heparinoids had minimal effects on SIPA. LMW heparin had less enhancing effect on SIPA than unfractionated heparin. Effects of heparin were also investigated using PRP from patients with congenital bleeding disorders, including Bernard-Soulier syndrome, type III von Willebrand's disease, afibrinogenemia and Glanzmann's thrombasthenia. Heparin's effects were observed only when PRP from patients with Bernard-Soulier syndrome and type III von Willebrand's disease was exposed to low shear stress and when PRP from a patient with afibrinogenemia was exposed to high shear stress. These results gave us insights into heparin's effects on platelet aggregation.

Original languageEnglish
Pages (from-to)60-65
Number of pages6
JournalSeminars in Thrombosis and Hemostasis
Volume16
Issue numberSUPPL.
Publication statusPublished - 1990

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ASJC Scopus subject areas

  • Hematology

Cite this

Kawano, K., Ikeda, Y., Handa, M., Kamata, T., Anbo, H., Araki, Y., Kawai, Y., Watanabe, K., Itagaki, I., Kawakami, K., Fukuyama, M., & Sakai, K. (1990). Enhancing effect by heparin on shear-induced platelet aggregation. Seminars in Thrombosis and Hemostasis, 16(SUPPL.), 60-65.