Entamoeba moshkovskii is associated with diarrhea in infants and causes diarrhea and colitis in mice

Chikako Shimokawa, Mamun Kabir, Mami Taniuchi, Dinesh Mondal, Seiki Kobayashi, Ibne Karim M Ali, Shihab U. Sobuz, Masachika Senba, Eric Houpt, Rashidul Haque, William A. Petri, Shinjiro Hamano

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Abstract

Background.Entamoeba moshkovskii is prevalent in developing countries and morphologically indistinguishable from pathogenic Entamoeba histolytica and nonpathogenic Entamoeba dispar. It is not known if E. moshkovskii is pathogenic.Methods.Mice were intracecally challenged with the trophozoites of each Entamoeba spp. to test the ability to cause diarrhea, and infants in Bangladesh were prospectively observed to see if newly acquired E. moshkovskii infection was associated with diarrhea.Results.E. moshkovskii and E. histolytica caused diarrhea and weight loss in susceptible mice. E. dispar infected none of the mouse strains tested. In Mirpur, Dhaka, Bangladesh, E. moshkovskii, E. histolytica, and E. dispar were identified in 42 (2.95), 66 (4.63), and 5 (0.35), respectively, of 1426 diarrheal episodes in 385 children followed prospectively from birth to one year of age. Diarrhea occurred temporally with acquisition of a new E. moshkovskii infection: in the 2 months preceding E. moshkvskii-associated diarrhea, 86 (36 of 42) of monthly surveillance stool samples were negative for E. moshkovskii.Conclusions.E. moshkovskii was found to be pathogenic in mice. In children, the acquisition of E. moshkovskii infection was associated with diarrhea. These data are consistent with E. moshkovskii causing disease, indicating that it is important to reexamine its pathogenicity.

Original languageEnglish
Pages (from-to)744-751
Number of pages8
JournalJournal of Infectious Diseases
Volume206
Issue number5
DOIs
Publication statusPublished - 2012 Sep 1

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Entamoeba
Colitis
Diarrhea
Entamoeba histolytica
Bangladesh
Infection
Trophozoites
Developing Countries
Virulence
Weight Loss
Parturition

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Shimokawa, C., Kabir, M., Taniuchi, M., Mondal, D., Kobayashi, S., Ali, I. K. M., ... Hamano, S. (2012). Entamoeba moshkovskii is associated with diarrhea in infants and causes diarrhea and colitis in mice. Journal of Infectious Diseases, 206(5), 744-751. https://doi.org/10.1093/infdis/jis414

Entamoeba moshkovskii is associated with diarrhea in infants and causes diarrhea and colitis in mice. / Shimokawa, Chikako; Kabir, Mamun; Taniuchi, Mami; Mondal, Dinesh; Kobayashi, Seiki; Ali, Ibne Karim M; Sobuz, Shihab U.; Senba, Masachika; Houpt, Eric; Haque, Rashidul; Petri, William A.; Hamano, Shinjiro.

In: Journal of Infectious Diseases, Vol. 206, No. 5, 01.09.2012, p. 744-751.

Research output: Contribution to journalArticle

Shimokawa, C, Kabir, M, Taniuchi, M, Mondal, D, Kobayashi, S, Ali, IKM, Sobuz, SU, Senba, M, Houpt, E, Haque, R, Petri, WA & Hamano, S 2012, 'Entamoeba moshkovskii is associated with diarrhea in infants and causes diarrhea and colitis in mice', Journal of Infectious Diseases, vol. 206, no. 5, pp. 744-751. https://doi.org/10.1093/infdis/jis414
Shimokawa, Chikako ; Kabir, Mamun ; Taniuchi, Mami ; Mondal, Dinesh ; Kobayashi, Seiki ; Ali, Ibne Karim M ; Sobuz, Shihab U. ; Senba, Masachika ; Houpt, Eric ; Haque, Rashidul ; Petri, William A. ; Hamano, Shinjiro. / Entamoeba moshkovskii is associated with diarrhea in infants and causes diarrhea and colitis in mice. In: Journal of Infectious Diseases. 2012 ; Vol. 206, No. 5. pp. 744-751.
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AU - Shimokawa, Chikako

AU - Kabir, Mamun

AU - Taniuchi, Mami

AU - Mondal, Dinesh

AU - Kobayashi, Seiki

AU - Ali, Ibne Karim M

AU - Sobuz, Shihab U.

AU - Senba, Masachika

AU - Houpt, Eric

AU - Haque, Rashidul

AU - Petri, William A.

AU - Hamano, Shinjiro

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N2 - Background.Entamoeba moshkovskii is prevalent in developing countries and morphologically indistinguishable from pathogenic Entamoeba histolytica and nonpathogenic Entamoeba dispar. It is not known if E. moshkovskii is pathogenic.Methods.Mice were intracecally challenged with the trophozoites of each Entamoeba spp. to test the ability to cause diarrhea, and infants in Bangladesh were prospectively observed to see if newly acquired E. moshkovskii infection was associated with diarrhea.Results.E. moshkovskii and E. histolytica caused diarrhea and weight loss in susceptible mice. E. dispar infected none of the mouse strains tested. In Mirpur, Dhaka, Bangladesh, E. moshkovskii, E. histolytica, and E. dispar were identified in 42 (2.95), 66 (4.63), and 5 (0.35), respectively, of 1426 diarrheal episodes in 385 children followed prospectively from birth to one year of age. Diarrhea occurred temporally with acquisition of a new E. moshkovskii infection: in the 2 months preceding E. moshkvskii-associated diarrhea, 86 (36 of 42) of monthly surveillance stool samples were negative for E. moshkovskii.Conclusions.E. moshkovskii was found to be pathogenic in mice. In children, the acquisition of E. moshkovskii infection was associated with diarrhea. These data are consistent with E. moshkovskii causing disease, indicating that it is important to reexamine its pathogenicity.

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