Enzymatic decarboxylation-An emerging reaction for chemicals production from renewable resources

Robert Kourist, Jan Karl Guterl, Kenji Miyamoto, Volker Sieber

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Decarboxylases are very useful tools for the defunctionalization of organic molecules under very mild reaction conditions. They have been applied for the synthesis of alcohols, carboxylic acids, diamines, terminal olefins, and other important chemicals. Moreover, several decarboxylases catalyze the fixation of carbon dioxide, which makes them promising catalysts for the utilization of this resource. Interestingly, several decarboxylases show promiscuous activities such as enzymatic racemization and stereoselective hydration. Despite this very high synthetic potential, large-scale processes are still rare and are mostly limited to fermentative approaches or to small-volume products. This Minireview gives an overview of the several recent, very promising applications both for the synthesis of high-value fine chemicals and biogenic bulk products and summarizes chances and limitations of this emerging class of biocatalysts. Defunct(ionalizing) organics: Enzymatic decarboxylation is an emerging tool for the defunctionalization of organic molecules. Recent applications span from the synthesis of high-value fine chemicals to the preparation of bio-based commodities.

Original languageEnglish
Pages (from-to)689-701
Number of pages13
JournalChemCatChem
Volume6
Issue number3
DOIs
Publication statusPublished - 2014 Mar

Fingerprint

decarboxylation
Carboxy-Lyases
emerging
resources
synthesis
commodities
Molecules
Biocatalysts
Diamines
Alkenes
products
diamines
Carboxylic Acids
Carboxylic acids
Carbon Dioxide
carboxylic acids
Hydration
alkenes
Olefins
hydration

Keywords

  • biocatalysis
  • biotechnology
  • carbon dioxide
  • enzyme catalysis
  • green chemistry

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Catalysis

Cite this

Enzymatic decarboxylation-An emerging reaction for chemicals production from renewable resources. / Kourist, Robert; Guterl, Jan Karl; Miyamoto, Kenji; Sieber, Volker.

In: ChemCatChem, Vol. 6, No. 3, 03.2014, p. 689-701.

Research output: Contribution to journalArticle

Kourist, Robert ; Guterl, Jan Karl ; Miyamoto, Kenji ; Sieber, Volker. / Enzymatic decarboxylation-An emerging reaction for chemicals production from renewable resources. In: ChemCatChem. 2014 ; Vol. 6, No. 3. pp. 689-701.
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