Abstract
Kinetic resolution of racemic 1-cyano-1-methylalkyl and alkenyl acetates has been achieved on incubation with Pichia miso IAM 4682, which hydolyzed selectively the (R)-enantiomer, leaving behind the (S)-enantiomer intact. The chiral 1-cyano-1-methyl-5-hexenyl acetate thus obtained was converted to (S)-(-)-frontalin via unsaturated diol.
| Original language | English |
|---|---|
| Pages (from-to) | 5469-5476 |
| Number of pages | 8 |
| Journal | Tetrahedron |
| Volume | 45 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - 1989 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Ohta, H., Kimura, Y., Sugano, Y., & Sugai, T. (1989). Enzymatic kinetic resolution of cyanohydrin acetates and its application to the synthesis of (S)-(-)-frontalin. Tetrahedron, 45(17), 5469-5476. https://doi.org/10.1016/S0040-4020(01)89493-X