Abstract
Kinetic resolution of racemic 1-cyano-1-methylalkyl and alkenyl acetates has been achieved on incubation with Pichia miso IAM 4682, which hydolyzed selectively the (R)-enantiomer, leaving behind the (S)-enantiomer intact. The chiral 1-cyano-1-methyl-5-hexenyl acetate thus obtained was converted to (S)-(-)-frontalin via unsaturated diol.
Original language | English |
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Pages (from-to) | 5469-5476 |
Number of pages | 8 |
Journal | Tetrahedron |
Volume | 45 |
Issue number | 17 |
DOIs | |
Publication status | Published - 1989 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry