Enzymatic synthesis of polythioester by the ring-opening polymerization of cyclic thioester

Makoto Kato, Kazunobu Toshima, Shuichi Matsumura

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A high molecular weight aliphatic polythioester was prepared by lipase-catalyzed polymerization of hexane-1,6-dithiol and dimethyl sebacate using the technique of ring-opening polymerization of a cyclic thioester. The cyclic thioester monomer was first prepared using lipase from Candida antarctica in dilute solution. The monomer was then polymerized by the same lipase in bulk to produce a polythioester with an Mw of about 120 000 g/mol, which was significantly higher than that of a polythioester obtained by direct polycondensation of the dithiol and diacid. The polymerization rate and thermal properties of the product were measured and compared with those of the corresponding polyester prepared by ring-opening polymerization of a cyclic ester.

Original languageEnglish
Pages (from-to)3590-3596
Number of pages7
JournalBiomacromolecules
Volume8
Issue number11
DOIs
Publication statusPublished - 2007 Nov 1

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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