Enzyme- and microorganism-mediated syntheses of substances related to glycoconjugates

Atsuhito Kuboki, Mikio Bakke, Takahiro Sekiguchi, Hiromichi Ohta, Takeshi Sugai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In this article, chemo-enzymatic syntheses of important substances which serve as the building blocks for glycoconjugate synthesis are described : 1) Sialic acid aldolase-catalyzed synthesis of sialic acids and its analogs ; 2) Studies on Rhodococcus rhodochrous IFO 15564-catalyzed degradation of N-acetyl-D-glucosamine and its derivatives ; 3) Hydration of carbohydrate nitriles mediated by a nitirle hydratase produced by R. rhodochrous IFO 15564 ; 4) Synthesis of N-acetyl-D-allosamine based on the lipase-catalyzed regioselective acetylation as the key step ; 5) Kinetic optical resolution of highly deoxygenated carbohydrate by means of lipase-catalyzed transesterification ; 6) Kinetic optical resolution of ceramide based on lipase-catalyzed hydrolysis.

Original languageEnglish
Pages (from-to)489-499
Number of pages11
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume56
Issue number6
Publication statusPublished - 1998 Jun

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Glycoconjugates
Microorganisms
Lipase
Enzymes
N-acetylneuraminate lyase
Carbohydrates
Hydro-Lyases
Sialic Acids
Acetylation
Nitriles
Kinetics
Acetylglucosamine
Ceramides
Transesterification
Hydration
Hydrolysis
Derivatives
Degradation

Keywords

  • Carbohydrates
  • Ceramides
  • Kinetic resolution
  • Microorganisms

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Enzyme- and microorganism-mediated syntheses of substances related to glycoconjugates. / Kuboki, Atsuhito; Bakke, Mikio; Sekiguchi, Takahiro; Ohta, Hiromichi; Sugai, Takeshi.

In: Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, Vol. 56, No. 6, 06.1998, p. 489-499.

Research output: Contribution to journalArticle

Kuboki, Atsuhito ; Bakke, Mikio ; Sekiguchi, Takahiro ; Ohta, Hiromichi ; Sugai, Takeshi. / Enzyme- and microorganism-mediated syntheses of substances related to glycoconjugates. In: Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 1998 ; Vol. 56, No. 6. pp. 489-499.
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