Eosinophil polyunsaturated fatty acid metabolism and its potential control of inflammation and allergy

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7 Citations (Scopus)

Abstract

Polyunsaturated fatty acids (PUFAs) exhibit a range of biological effects, many of which are mediated through the formation and actions of their bioactive metabolites. It is well appreciated that dietary PUFA balance affects inflammation and/or allergic diseases, and recent advances in liquid chromatography tandem mass spectrometry (LC-MS/MS)-based mediator lipidomics have revealed a potential link between PUFA metabolism and biological phenotypes. This review presents insights into the emerging roles of eosinophil PUFA metabolism in controlling inflammatory responses and its potential involvement in allergy control.

Original languageEnglish
JournalAllergology International
DOIs
Publication statusAccepted/In press - 2016 May 20

Keywords

  • Eosinophil
  • Lipid mediator
  • Lipidomics
  • Lipoxygenase
  • N-3 fatty acid

ASJC Scopus subject areas

  • Immunology and Allergy

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