Eotaxin and monocyte chemoattractant protein-1 in chronic eosinophilic pneumonia

H. Tateno, H. Nakamura, N. Minematsu, K. Amakawa, T. Terashima, Seitaro Fujishima, A. D. Luster, C. M. Lilly, K. Yamaguchi

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Abstract

Chronic eosinophilic pneumonia (CEP) is characterized by chronic or recurrent pulmonary infiltrates with eosinophils, but the precise mechanism of eosinophil accumulation has not been fully elucidated. Eotaxin is one of the CC chemokines that selectively recruits eosinophils and contributes to the pathogenesis of allergic airway disease including asthma, but its roles in pathogenesis of CEP have not been fully elucidated. The authors measured concentrations of eotaxin and other CC chemokines, monocyte chemoattractant protein-1 (MCP-1), regulated on activation, normal T-cell expressed and secreted, macrophage inflammatory protein-1α, and the eosinophil activating Th2 cytokine interleukin (IL)-5 in bronchoalveolar lavage (BAL) fluid from CEP patients (n = 11), and compared these concentrations with those from control subjects (n = 6). The eotaxin (904 ± 203 versus 29 ± 7 pg·mL-1, p = 0.0001), MCP-1 (194 ± 57 versus 15 ± 2 pg·mL-1, p < 0.05), and IL-5 (7.8 ± 2.0 versus 2.7 ± 0.6 pg·mL-1, p < 0.05) levels were significantly higher for cases with CEP in comparison to those serving as controls. Proportions of eosinophil and lymphocyte counts were greater in BAL fluid from CEP patients. Eotaxin and IL-5 levels correlated with the proportion of eosinophils in BAL fluid from CEP patients. MCP-1 correlated with the relative lymphocyte numbers. In short, eotaxin, interleukin-5, and monocyte chemoattractant protein-1 levels were higher in the BAL fluid of CEP patients and these levels may contribute to eosinophil and lymphocyte recruitment and activation in the airways as found with this disorder.

Original languageEnglish
Pages (from-to)962-968
Number of pages7
JournalEuropean Respiratory Journal
Volume17
Issue number5
DOIs
Publication statusPublished - 2001

Fingerprint

Chemokine CCL2
Eosinophils
Interleukin-5
Bronchoalveolar Lavage Fluid
CC Chemokines
Lymphocyte Count
Macrophage Inflammatory Proteins
Lymphocyte Activation
Carrington syndrome
Asthma
Cytokines
T-Lymphocytes
Lung

Keywords

  • Bronchoalveolar lavage
  • Chronic eosinophilic pneumonia
  • Eotaxin
  • Interleukin-5
  • Interstitial lung disease
  • Monocyte chemoattractant protein-1

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Tateno, H., Nakamura, H., Minematsu, N., Amakawa, K., Terashima, T., Fujishima, S., ... Yamaguchi, K. (2001). Eotaxin and monocyte chemoattractant protein-1 in chronic eosinophilic pneumonia. European Respiratory Journal, 17(5), 962-968. https://doi.org/10.1183/09031936.01.17509620

Eotaxin and monocyte chemoattractant protein-1 in chronic eosinophilic pneumonia. / Tateno, H.; Nakamura, H.; Minematsu, N.; Amakawa, K.; Terashima, T.; Fujishima, Seitaro; Luster, A. D.; Lilly, C. M.; Yamaguchi, K.

In: European Respiratory Journal, Vol. 17, No. 5, 2001, p. 962-968.

Research output: Contribution to journalArticle

Tateno, H, Nakamura, H, Minematsu, N, Amakawa, K, Terashima, T, Fujishima, S, Luster, AD, Lilly, CM & Yamaguchi, K 2001, 'Eotaxin and monocyte chemoattractant protein-1 in chronic eosinophilic pneumonia', European Respiratory Journal, vol. 17, no. 5, pp. 962-968. https://doi.org/10.1183/09031936.01.17509620
Tateno, H. ; Nakamura, H. ; Minematsu, N. ; Amakawa, K. ; Terashima, T. ; Fujishima, Seitaro ; Luster, A. D. ; Lilly, C. M. ; Yamaguchi, K. / Eotaxin and monocyte chemoattractant protein-1 in chronic eosinophilic pneumonia. In: European Respiratory Journal. 2001 ; Vol. 17, No. 5. pp. 962-968.
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