Eph and ephrin interactions in bone

Research output: Chapter in Book/Report/Conference proceedingConference contribution

28 Citations (Scopus)

Abstract

Bone cells communicate with each other using various cell surface molecules. Membrane-bound ephrin ligands and Eph tyrosine kinase receptors have been characterized in diverse biological processes, including angiogenesis and neuronal development. Several ephrins and Ephs are expressed in osteoclasts and osteoblasts and regulate bone mineral metabolism through bidirectional signaling into not only receptor-expressing cells but also into ligand-expressing cells. We propose that interaction between ephrinB2-expressing osteoclasts and EphB4-expressing osteoblasts facilitates the transition from bone resorption to bone formation during bone remodeling. Other groups have reported the regulation of ephrinB2 by PTH or PTHrP and the possible involvement of EphB4 in osteoarthritis. It is likely that various ephrins and Ephs mediate interaction among bone cells.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Pages95-103
Number of pages9
Volume658
DOIs
Publication statusPublished - 2010

Publication series

NameAdvances in Experimental Medicine and Biology
Volume658
ISSN (Print)00652598

Fingerprint

Ephrins
Bone
Bone and Bones
Osteoclasts
Osteoblasts
Eph Family Receptors
Ligands
Biological Phenomena
Parathyroid Hormone-Related Protein
Bone Remodeling
Bone Resorption
Osteogenesis
Osteoarthritis
Minerals
Metabolism
Membranes
Molecules

Keywords

  • Bone remodeling
  • Eph
  • Ephrin
  • Osteoclast

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Matsuo, K. (2010). Eph and ephrin interactions in bone. In Advances in Experimental Medicine and Biology (Vol. 658, pp. 95-103). (Advances in Experimental Medicine and Biology; Vol. 658). https://doi.org/10.1007/978-1-4419-1050-9_10

Eph and ephrin interactions in bone. / Matsuo, Koichi.

Advances in Experimental Medicine and Biology. Vol. 658 2010. p. 95-103 (Advances in Experimental Medicine and Biology; Vol. 658).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Matsuo, K 2010, Eph and ephrin interactions in bone. in Advances in Experimental Medicine and Biology. vol. 658, Advances in Experimental Medicine and Biology, vol. 658, pp. 95-103. https://doi.org/10.1007/978-1-4419-1050-9_10
Matsuo K. Eph and ephrin interactions in bone. In Advances in Experimental Medicine and Biology. Vol. 658. 2010. p. 95-103. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4419-1050-9_10
Matsuo, Koichi. / Eph and ephrin interactions in bone. Advances in Experimental Medicine and Biology. Vol. 658 2010. pp. 95-103 (Advances in Experimental Medicine and Biology).
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