Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population

Kenji Amamoto, Tomonori Okamura, Shinji Tamaki, Yoshikuni Kita, Yasuyuki Tsujita, Takashi Kadowaki, Yasuyuki Nakamura, Hirotsugu Ueshima

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

In Japanese and other Asians, the prevalence of genetically decreased mitochondrial aldehyde dehydrogenase (ALDH2) activity is higher than in Caucasians. The aim of this study was to elucidate the relation between ALDH2 genotypes and blood pressure levels or hypertension in Japanese. After obtaining informed consent for genetic analysis from 917 men and 1,478 women who lived in a mountainous farming region near Kyoto and who were free from cardiovascular disease and liver dysfunction, the authors identified the ALDH2 genotype in all subjects. Differences in blood pressure level among genotypes were then compared by analysis of covariance, and the relation between genotypes and hypertension was also analyzed by logistic regression analysis. The frequencies of genotypes *1/*1, *1/*2, and *2/*2 were 44.7%, 46.9% and 8.4% in men, and 50.1%, 43.2% and 6.8% in women, respectively. In men, systolic and diastolic blood pressures tended to decrease in the order of *1/*1>*1/*2>*2/*2. However, adjustment for confounding factors including alcohol consumption resulted in the disappearance of significance. Logistic regression analysis adjusted for the same confounding factors for men showed that the odds ratios (OR) of being hypertensive in the *2 allele to not having *2 allele were 0.67 (95% confidence interval (CI): 0.47-0.96). However, in the subgroup analyses, this relation was not observed in the group having a below-median level of alcohol consumption (OR=0.92; 95% CI: 0.53-1.62) or in the group not taking antihypertensive agents (OR=0.77; 95% CI: 0.52-1.15). Furthermore, we did not observe any relation between the ALDH2/*2 allele and hypertension in women (OR=1.07; 95% CI: 0.80-1.42). The results suggest that there may be no causal relation between hypertension and the ALDH2 genotype per se, after excluding for some confounding factors, especially for alcohol drinking.

Original languageEnglish
Pages (from-to)857-864
Number of pages8
JournalHypertension Research
Volume25
Issue number6
Publication statusPublished - 2002 Nov
Externally publishedYes

Fingerprint

Epidemiologic Studies
Genotype
Blood Pressure
Hypertension
Odds Ratio
Alcohol Drinking
Confidence Intervals
Population
Alleles
Logistic Models
Regression Analysis
Agriculture
Informed Consent
Antihypertensive Agents
aldehyde dehydrogenase (NAD(P)+)
Liver Diseases
Cardiovascular Diseases

Keywords

  • Alchohol
  • Aldehyde dehydrogenase 2
  • Blood pressure
  • Genetic
  • Hypertension

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population. / Amamoto, Kenji; Okamura, Tomonori; Tamaki, Shinji; Kita, Yoshikuni; Tsujita, Yasuyuki; Kadowaki, Takashi; Nakamura, Yasuyuki; Ueshima, Hirotsugu.

In: Hypertension Research, Vol. 25, No. 6, 11.2002, p. 857-864.

Research output: Contribution to journalArticle

Amamoto, Kenji ; Okamura, Tomonori ; Tamaki, Shinji ; Kita, Yoshikuni ; Tsujita, Yasuyuki ; Kadowaki, Takashi ; Nakamura, Yasuyuki ; Ueshima, Hirotsugu. / Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population. In: Hypertension Research. 2002 ; Vol. 25, No. 6. pp. 857-864.
@article{03033cd8099d4aa38d8430b799a8b50b,
title = "Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population",
abstract = "In Japanese and other Asians, the prevalence of genetically decreased mitochondrial aldehyde dehydrogenase (ALDH2) activity is higher than in Caucasians. The aim of this study was to elucidate the relation between ALDH2 genotypes and blood pressure levels or hypertension in Japanese. After obtaining informed consent for genetic analysis from 917 men and 1,478 women who lived in a mountainous farming region near Kyoto and who were free from cardiovascular disease and liver dysfunction, the authors identified the ALDH2 genotype in all subjects. Differences in blood pressure level among genotypes were then compared by analysis of covariance, and the relation between genotypes and hypertension was also analyzed by logistic regression analysis. The frequencies of genotypes *1/*1, *1/*2, and *2/*2 were 44.7{\%}, 46.9{\%} and 8.4{\%} in men, and 50.1{\%}, 43.2{\%} and 6.8{\%} in women, respectively. In men, systolic and diastolic blood pressures tended to decrease in the order of *1/*1>*1/*2>*2/*2. However, adjustment for confounding factors including alcohol consumption resulted in the disappearance of significance. Logistic regression analysis adjusted for the same confounding factors for men showed that the odds ratios (OR) of being hypertensive in the *2 allele to not having *2 allele were 0.67 (95{\%} confidence interval (CI): 0.47-0.96). However, in the subgroup analyses, this relation was not observed in the group having a below-median level of alcohol consumption (OR=0.92; 95{\%} CI: 0.53-1.62) or in the group not taking antihypertensive agents (OR=0.77; 95{\%} CI: 0.52-1.15). Furthermore, we did not observe any relation between the ALDH2/*2 allele and hypertension in women (OR=1.07; 95{\%} CI: 0.80-1.42). The results suggest that there may be no causal relation between hypertension and the ALDH2 genotype per se, after excluding for some confounding factors, especially for alcohol drinking.",
keywords = "Alchohol, Aldehyde dehydrogenase 2, Blood pressure, Genetic, Hypertension",
author = "Kenji Amamoto and Tomonori Okamura and Shinji Tamaki and Yoshikuni Kita and Yasuyuki Tsujita and Takashi Kadowaki and Yasuyuki Nakamura and Hirotsugu Ueshima",
year = "2002",
month = "11",
language = "English",
volume = "25",
pages = "857--864",
journal = "Hypertension Research",
issn = "0916-9636",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population

AU - Amamoto, Kenji

AU - Okamura, Tomonori

AU - Tamaki, Shinji

AU - Kita, Yoshikuni

AU - Tsujita, Yasuyuki

AU - Kadowaki, Takashi

AU - Nakamura, Yasuyuki

AU - Ueshima, Hirotsugu

PY - 2002/11

Y1 - 2002/11

N2 - In Japanese and other Asians, the prevalence of genetically decreased mitochondrial aldehyde dehydrogenase (ALDH2) activity is higher than in Caucasians. The aim of this study was to elucidate the relation between ALDH2 genotypes and blood pressure levels or hypertension in Japanese. After obtaining informed consent for genetic analysis from 917 men and 1,478 women who lived in a mountainous farming region near Kyoto and who were free from cardiovascular disease and liver dysfunction, the authors identified the ALDH2 genotype in all subjects. Differences in blood pressure level among genotypes were then compared by analysis of covariance, and the relation between genotypes and hypertension was also analyzed by logistic regression analysis. The frequencies of genotypes *1/*1, *1/*2, and *2/*2 were 44.7%, 46.9% and 8.4% in men, and 50.1%, 43.2% and 6.8% in women, respectively. In men, systolic and diastolic blood pressures tended to decrease in the order of *1/*1>*1/*2>*2/*2. However, adjustment for confounding factors including alcohol consumption resulted in the disappearance of significance. Logistic regression analysis adjusted for the same confounding factors for men showed that the odds ratios (OR) of being hypertensive in the *2 allele to not having *2 allele were 0.67 (95% confidence interval (CI): 0.47-0.96). However, in the subgroup analyses, this relation was not observed in the group having a below-median level of alcohol consumption (OR=0.92; 95% CI: 0.53-1.62) or in the group not taking antihypertensive agents (OR=0.77; 95% CI: 0.52-1.15). Furthermore, we did not observe any relation between the ALDH2/*2 allele and hypertension in women (OR=1.07; 95% CI: 0.80-1.42). The results suggest that there may be no causal relation between hypertension and the ALDH2 genotype per se, after excluding for some confounding factors, especially for alcohol drinking.

AB - In Japanese and other Asians, the prevalence of genetically decreased mitochondrial aldehyde dehydrogenase (ALDH2) activity is higher than in Caucasians. The aim of this study was to elucidate the relation between ALDH2 genotypes and blood pressure levels or hypertension in Japanese. After obtaining informed consent for genetic analysis from 917 men and 1,478 women who lived in a mountainous farming region near Kyoto and who were free from cardiovascular disease and liver dysfunction, the authors identified the ALDH2 genotype in all subjects. Differences in blood pressure level among genotypes were then compared by analysis of covariance, and the relation between genotypes and hypertension was also analyzed by logistic regression analysis. The frequencies of genotypes *1/*1, *1/*2, and *2/*2 were 44.7%, 46.9% and 8.4% in men, and 50.1%, 43.2% and 6.8% in women, respectively. In men, systolic and diastolic blood pressures tended to decrease in the order of *1/*1>*1/*2>*2/*2. However, adjustment for confounding factors including alcohol consumption resulted in the disappearance of significance. Logistic regression analysis adjusted for the same confounding factors for men showed that the odds ratios (OR) of being hypertensive in the *2 allele to not having *2 allele were 0.67 (95% confidence interval (CI): 0.47-0.96). However, in the subgroup analyses, this relation was not observed in the group having a below-median level of alcohol consumption (OR=0.92; 95% CI: 0.53-1.62) or in the group not taking antihypertensive agents (OR=0.77; 95% CI: 0.52-1.15). Furthermore, we did not observe any relation between the ALDH2/*2 allele and hypertension in women (OR=1.07; 95% CI: 0.80-1.42). The results suggest that there may be no causal relation between hypertension and the ALDH2 genotype per se, after excluding for some confounding factors, especially for alcohol drinking.

KW - Alchohol

KW - Aldehyde dehydrogenase 2

KW - Blood pressure

KW - Genetic

KW - Hypertension

UR - http://www.scopus.com/inward/record.url?scp=0036868189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036868189&partnerID=8YFLogxK

M3 - Article

C2 - 12484509

AN - SCOPUS:0036868189

VL - 25

SP - 857

EP - 864

JO - Hypertension Research

JF - Hypertension Research

SN - 0916-9636

IS - 6

ER -