Epidemiological survey of ossification of the posterior longitudinal ligament by using clinical investigation registration forms

Takashi Tsuji, Kazuhiro Chiba, Naobumi Hosogane, Nobuyuki Fujita, Tomohiro Hikata, Akio Iwanami, Kota Watanabe, Ken Ishii, Yoshiaki Toyama, Masaya Nakamura, Morio Matsumoto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background In Japan, ossification of the posterior longitudinal ligament (OPLL) has been designated as an intractable disease by the Ministry of Health, Labour, and Welfare. Here we aimed to clarify the epidemiological characteristics of severe OPLL patients by analyzing a national registry of this disease that uses clinical investigation registration forms. Methods We retrospectively investigated clinical investigation registration forms for 24,502 patients with OPLL. We examined the sex distribution, age of disease onset, period from disease onset to registration, family history, site of ossification as determined by plain radiographs, Japanese Orthopaedic Association score, and number of OPLL surgeries. Results The male-to-female ratios were 2.7:1 and 1.9:1 for new and renewed registrations, respectively. The mean ages at disease onset were 61.1 and 59.7 years for new and renewed registrations, respectively. The mean periods from disease onset to registration were 2.6 and 8.4 years for new and renewed registrations, respectively. The percentages of new registrations with and without family history were 5.3% and 51.5%, respectively (unknown for 43.3%). Of the new registrations, 3511, 359, and 200 cases exhibited ossification in the cervical spine, thoracic spine, and lumbar spine, respectively; the corresponding numbers for renewed registrations were 13,710, 2484, and 1508. The Japanese Orthopaedic Association score was 9.9 ± 3.6 for new registrations, and the mean score recovery rate for renewed registrations was 6.0%. The number of OPLL surgeries was one or zero, two, three, four, or five for 21,785, 2167, 412, 99, and 39 patients, respectively, with 11.1% of all patients having undergone multiple surgeries. Conclusions This study offers new insight into the epidemiological characteristics of severe OPLL. In particular, we found that the age of disease onset was higher than previously reported, the period from disease onset to registration (surgery) was relatively short, and about 90% of the patients required only a single surgery.

Original languageEnglish
Pages (from-to)291-294
Number of pages4
JournalJournal of Orthopaedic Science
Volume21
Issue number3
DOIs
Publication statusPublished - 2016 May 1

ASJC Scopus subject areas

  • Medicine(all)
  • Orthopedics and Sports Medicine

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