Epidermal keratinocytes as the forefront of the sensory system

Mitsuhiro Denda, Masashi Nakatani, Kazuyuki Ikeyama, Moe Tsutsumi, Sumiko Denda

Research output: Contribution to journalReview article

98 Citations (Scopus)

Abstract

Various sensors that respond to physical or chemical environmental factors have been identified in the peripheral nervous system. Some of them, which respond to mechanical stress, osmotic pressure, temperature and chemical stimuli (such as pH), are also expressed in epidermal keratinocytes. Neurotransmitters and their receptors, as well as receptors that regulate the neuroendocrine system of the skin, are also present in keratinocytes. Thus, broadly speaking, epidermal keratinocytes appear to be equipped with sensing systems similar to those of the peripheral and central nervous systems. It had long been considered that only nerve C-terminals in the epidermis play a role in skin surface perception. However, building on earlier work on skin receptors and new findings introduced here, we present in this review a novel hypothesis of skin sensory perception, i.e. first, keratinocytes recognize various environmental factors, and then the information is processed and conveyed to the nervous system.

Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalExperimental Dermatology
Volume16
Issue number3
DOIs
Publication statusPublished - 2007 Mar
Externally publishedYes

Fingerprint

Keratinocytes
Skin
Neurology
Peripheral Nervous System
Neurosecretory Systems
Mechanical Stress
Neurotransmitter Receptor
Osmotic Pressure
Epidermis
Nervous System
Central Nervous System
Temperature
Sensors

Keywords

  • Nervous system
  • Neurotransmitter
  • P2X
  • Skin perception
  • Transient receptor potential

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

Epidermal keratinocytes as the forefront of the sensory system. / Denda, Mitsuhiro; Nakatani, Masashi; Ikeyama, Kazuyuki; Tsutsumi, Moe; Denda, Sumiko.

In: Experimental Dermatology, Vol. 16, No. 3, 03.2007, p. 157-161.

Research output: Contribution to journalReview article

Denda, Mitsuhiro ; Nakatani, Masashi ; Ikeyama, Kazuyuki ; Tsutsumi, Moe ; Denda, Sumiko. / Epidermal keratinocytes as the forefront of the sensory system. In: Experimental Dermatology. 2007 ; Vol. 16, No. 3. pp. 157-161.
@article{45e27aec1c7749e0a802917233f5f18c,
title = "Epidermal keratinocytes as the forefront of the sensory system",
abstract = "Various sensors that respond to physical or chemical environmental factors have been identified in the peripheral nervous system. Some of them, which respond to mechanical stress, osmotic pressure, temperature and chemical stimuli (such as pH), are also expressed in epidermal keratinocytes. Neurotransmitters and their receptors, as well as receptors that regulate the neuroendocrine system of the skin, are also present in keratinocytes. Thus, broadly speaking, epidermal keratinocytes appear to be equipped with sensing systems similar to those of the peripheral and central nervous systems. It had long been considered that only nerve C-terminals in the epidermis play a role in skin surface perception. However, building on earlier work on skin receptors and new findings introduced here, we present in this review a novel hypothesis of skin sensory perception, i.e. first, keratinocytes recognize various environmental factors, and then the information is processed and conveyed to the nervous system.",
keywords = "Nervous system, Neurotransmitter, P2X, Skin perception, Transient receptor potential",
author = "Mitsuhiro Denda and Masashi Nakatani and Kazuyuki Ikeyama and Moe Tsutsumi and Sumiko Denda",
year = "2007",
month = "3",
doi = "10.1111/j.1600-0625.2006.00529.x",
language = "English",
volume = "16",
pages = "157--161",
journal = "Experimental Dermatology",
issn = "0906-6705",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Epidermal keratinocytes as the forefront of the sensory system

AU - Denda, Mitsuhiro

AU - Nakatani, Masashi

AU - Ikeyama, Kazuyuki

AU - Tsutsumi, Moe

AU - Denda, Sumiko

PY - 2007/3

Y1 - 2007/3

N2 - Various sensors that respond to physical or chemical environmental factors have been identified in the peripheral nervous system. Some of them, which respond to mechanical stress, osmotic pressure, temperature and chemical stimuli (such as pH), are also expressed in epidermal keratinocytes. Neurotransmitters and their receptors, as well as receptors that regulate the neuroendocrine system of the skin, are also present in keratinocytes. Thus, broadly speaking, epidermal keratinocytes appear to be equipped with sensing systems similar to those of the peripheral and central nervous systems. It had long been considered that only nerve C-terminals in the epidermis play a role in skin surface perception. However, building on earlier work on skin receptors and new findings introduced here, we present in this review a novel hypothesis of skin sensory perception, i.e. first, keratinocytes recognize various environmental factors, and then the information is processed and conveyed to the nervous system.

AB - Various sensors that respond to physical or chemical environmental factors have been identified in the peripheral nervous system. Some of them, which respond to mechanical stress, osmotic pressure, temperature and chemical stimuli (such as pH), are also expressed in epidermal keratinocytes. Neurotransmitters and their receptors, as well as receptors that regulate the neuroendocrine system of the skin, are also present in keratinocytes. Thus, broadly speaking, epidermal keratinocytes appear to be equipped with sensing systems similar to those of the peripheral and central nervous systems. It had long been considered that only nerve C-terminals in the epidermis play a role in skin surface perception. However, building on earlier work on skin receptors and new findings introduced here, we present in this review a novel hypothesis of skin sensory perception, i.e. first, keratinocytes recognize various environmental factors, and then the information is processed and conveyed to the nervous system.

KW - Nervous system

KW - Neurotransmitter

KW - P2X

KW - Skin perception

KW - Transient receptor potential

UR - http://www.scopus.com/inward/record.url?scp=33846987220&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846987220&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0625.2006.00529.x

DO - 10.1111/j.1600-0625.2006.00529.x

M3 - Review article

C2 - 17286806

AN - SCOPUS:33846987220

VL - 16

SP - 157

EP - 161

JO - Experimental Dermatology

JF - Experimental Dermatology

SN - 0906-6705

IS - 3

ER -