Abstract
Purpose: To examine the hypothesis that epidural anesthesia throughout lower abdominal surgery would depress both postoperative pain and cortisol release. Methods: Forty adult patients undergoing abdominal total hysterectomy were studied. The patients were randomly assigned to two groups. Group G received general anesthesia alone (sevoflurane 1.5%-2.5%); group E received a combination of epidural anesthesia (1.5% mepivacaine) with a light plane of general anesthesia (sevoflurane<0.5%). Postoperative analgesia was obtained epidurally by patient-controlled analgesia. Postoperative pain at rest and during movement was assessed by a visual analogue scale (VAS) at 2, 24, and 48 h following surgery. The plasma concentration and urinary excretion of cortisol were measured during the perioperative period. Results: VAS values were lower in group E than in group G during movement at 24h (4.6±0.5 vs 6.1±0.4 cm). Urinary cortisol excretion on the first postoperative day was less in group E than in group G (192±34 vs 480±120μg). Conclusions: Epidural blockade prior to surgical stimuli and throughout lower abdominal surgery reduces the postoperative dynamic pain and stress response.
| Original language | English |
|---|---|
| Pages (from-to) | 260-264 |
| Number of pages | 5 |
| Journal | Journal of Anesthesia |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1997 Dec |
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Keywords
- Cortisol
- Epidural anesthesia
- Hysterectomy
- Preemptive analgesia
- Visual analogue scale
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Cite this
Epidural anesthesia during hysterectomy diminishes postoperative pain and urinary cortisol release. / Yorozu, Tomoko; Morisaki, Hiroshi; Kondoh, Masahiro; Tomizawa, Kazuo; Satoh, Masato; Shigematsu, Toshiyuki.
In: Journal of Anesthesia, Vol. 11, No. 4, 12.1997, p. 260-264.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epidural anesthesia during hysterectomy diminishes postoperative pain and urinary cortisol release
AU - Yorozu, Tomoko
AU - Morisaki, Hiroshi
AU - Kondoh, Masahiro
AU - Tomizawa, Kazuo
AU - Satoh, Masato
AU - Shigematsu, Toshiyuki
PY - 1997/12
Y1 - 1997/12
N2 - Purpose: To examine the hypothesis that epidural anesthesia throughout lower abdominal surgery would depress both postoperative pain and cortisol release. Methods: Forty adult patients undergoing abdominal total hysterectomy were studied. The patients were randomly assigned to two groups. Group G received general anesthesia alone (sevoflurane 1.5%-2.5%); group E received a combination of epidural anesthesia (1.5% mepivacaine) with a light plane of general anesthesia (sevoflurane<0.5%). Postoperative analgesia was obtained epidurally by patient-controlled analgesia. Postoperative pain at rest and during movement was assessed by a visual analogue scale (VAS) at 2, 24, and 48 h following surgery. The plasma concentration and urinary excretion of cortisol were measured during the perioperative period. Results: VAS values were lower in group E than in group G during movement at 24h (4.6±0.5 vs 6.1±0.4 cm). Urinary cortisol excretion on the first postoperative day was less in group E than in group G (192±34 vs 480±120μg). Conclusions: Epidural blockade prior to surgical stimuli and throughout lower abdominal surgery reduces the postoperative dynamic pain and stress response.
AB - Purpose: To examine the hypothesis that epidural anesthesia throughout lower abdominal surgery would depress both postoperative pain and cortisol release. Methods: Forty adult patients undergoing abdominal total hysterectomy were studied. The patients were randomly assigned to two groups. Group G received general anesthesia alone (sevoflurane 1.5%-2.5%); group E received a combination of epidural anesthesia (1.5% mepivacaine) with a light plane of general anesthesia (sevoflurane<0.5%). Postoperative analgesia was obtained epidurally by patient-controlled analgesia. Postoperative pain at rest and during movement was assessed by a visual analogue scale (VAS) at 2, 24, and 48 h following surgery. The plasma concentration and urinary excretion of cortisol were measured during the perioperative period. Results: VAS values were lower in group E than in group G during movement at 24h (4.6±0.5 vs 6.1±0.4 cm). Urinary cortisol excretion on the first postoperative day was less in group E than in group G (192±34 vs 480±120μg). Conclusions: Epidural blockade prior to surgical stimuli and throughout lower abdominal surgery reduces the postoperative dynamic pain and stress response.
KW - Cortisol
KW - Epidural anesthesia
KW - Hysterectomy
KW - Preemptive analgesia
KW - Visual analogue scale
UR - http://www.scopus.com/inward/record.url?scp=0031471569&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031471569&partnerID=8YFLogxK
U2 - 10.1007/BF02480741
DO - 10.1007/BF02480741
M3 - Article
AN - SCOPUS:0031471569
VL - 11
SP - 260
EP - 264
JO - Journal of Anesthesia
JF - Journal of Anesthesia
SN - 0913-8668
IS - 4
ER -