Epigenetic activation of tumor suppressor microRNAs in human cancer cells

Yoshimasa Saito; Peter A. Jones

doi:10.4161/cc.5.19.3340

Epigenetic activation of tumor suppressor microRNAs in human cancer cells

Yoshimasa Saito, Peter A. Jones

Research output: Contribution to journal › Short survey › peer-review

227 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that function as endogenous posttranscriptional silencers of target genes. miRNAs are expressed in a tissue specific manner and play important roles in cell proliferation, apoptosis and differentiation during animal development. Recent studies have shown a distinct connection between aberrant expression of miRNAs and the development of cancer, suggesting that miRNAs can be potential therapeutic targets. Our recent study has shown that some miRNAs are controlled by epigenetic alterations such as DNA methylation and histone modification in human cancer cells. Activation of tumor suppressor miRNAs by chromatin modifying drugs may cause downregulation of target oncogenes and could be a novel strategy for the prevention and treatment of human cancer.

Original language	English
Pages (from-to)	2220-2222
Number of pages	3
Journal	Cell Cycle
Volume	5
Issue number	19
DOIs	https://doi.org/10.4161/cc.5.19.3340
Publication status	Published - 2006 Oct 1
Externally published	Yes

Keywords

DNA methylation
Epigenetic therapy of cancer
Histone modification
MicroRNA

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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title = "Epigenetic activation of tumor suppressor microRNAs in human cancer cells",

abstract = "MicroRNAs (miRNAs) are small non-coding RNAs that function as endogenous posttranscriptional silencers of target genes. miRNAs are expressed in a tissue specific manner and play important roles in cell proliferation, apoptosis and differentiation during animal development. Recent studies have shown a distinct connection between aberrant expression of miRNAs and the development of cancer, suggesting that miRNAs can be potential therapeutic targets. Our recent study has shown that some miRNAs are controlled by epigenetic alterations such as DNA methylation and histone modification in human cancer cells. Activation of tumor suppressor miRNAs by chromatin modifying drugs may cause downregulation of target oncogenes and could be a novel strategy for the prevention and treatment of human cancer.",

keywords = "DNA methylation, Epigenetic therapy of cancer, Histone modification, MicroRNA",

author = "Yoshimasa Saito and Jones, {Peter A.}",

note = "Funding Information: This work was supported by grants from National Institute of Health grant RO1 CA 82422 (P.A.J.) and the Uehara Memorial Foundation of Japan (Y.S.).",

year = "2006",

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T1 - Epigenetic activation of tumor suppressor microRNAs in human cancer cells

AU - Saito, Yoshimasa

AU - Jones, Peter A.

N1 - Funding Information: This work was supported by grants from National Institute of Health grant RO1 CA 82422 (P.A.J.) and the Uehara Memorial Foundation of Japan (Y.S.).

PY - 2006/10/1

Y1 - 2006/10/1

N2 - MicroRNAs (miRNAs) are small non-coding RNAs that function as endogenous posttranscriptional silencers of target genes. miRNAs are expressed in a tissue specific manner and play important roles in cell proliferation, apoptosis and differentiation during animal development. Recent studies have shown a distinct connection between aberrant expression of miRNAs and the development of cancer, suggesting that miRNAs can be potential therapeutic targets. Our recent study has shown that some miRNAs are controlled by epigenetic alterations such as DNA methylation and histone modification in human cancer cells. Activation of tumor suppressor miRNAs by chromatin modifying drugs may cause downregulation of target oncogenes and could be a novel strategy for the prevention and treatment of human cancer.

AB - MicroRNAs (miRNAs) are small non-coding RNAs that function as endogenous posttranscriptional silencers of target genes. miRNAs are expressed in a tissue specific manner and play important roles in cell proliferation, apoptosis and differentiation during animal development. Recent studies have shown a distinct connection between aberrant expression of miRNAs and the development of cancer, suggesting that miRNAs can be potential therapeutic targets. Our recent study has shown that some miRNAs are controlled by epigenetic alterations such as DNA methylation and histone modification in human cancer cells. Activation of tumor suppressor miRNAs by chromatin modifying drugs may cause downregulation of target oncogenes and could be a novel strategy for the prevention and treatment of human cancer.

KW - DNA methylation

KW - Epigenetic therapy of cancer

KW - Histone modification

KW - MicroRNA

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