Epigenetic mechanisms regulating fate specification of neural stem cells

Masakazu Namihira, Jun Kohyama, Masahiko Abematsu, Kinichi Nakashima

Research output: Contribution to journalReview article

61 Citations (Scopus)

Abstract

Neural stem cells (NSCs) possess the ability to self-renew and to differentiate along neuronal and glial lineages. These processes are defined by the dynamic interplay between extracellular cues including cytokine signalling and intracellular programmes such as epigenetic modification. There is increasing evidence that epigenetic mechanisms involving, for example, changes in DNA methylation, histone modification and non-coding RNA expression are closely associated with fate specification of NSCs. These epigenetic alterations could provide coordinated systems for regulating gene expression at each step of neural cell differentiation. Here we review the roles of epigenetics in neural fate specification in the mammalian central nervous system.

Original languageEnglish
Pages (from-to)2099-2109
Number of pages11
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume363
Issue number1500
DOIs
Publication statusPublished - 2008 Jun 27
Externally publishedYes

Keywords

  • Chromatin remodelling
  • DNA methylation
  • Epigenetics
  • Histone modification
  • Neural stem cell
  • Non-coding RNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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