Epigenetic regulation of T helper cells and intestinal pathogenicity

Yuya Hagihara, Yusuke Yoshimatsu, Yohei Mikami, Yoshiaki Takada, Shinta Mizuno, Takanori Kanai

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Inflammatory bowel diseases (IBDs) are characterized by relapsing and remitting chronic intestinal inflammation. Previous studies have demonstrated the contributions of genetic background, environmental factors (food, microbiota, use of antibiotics), and host immunity in the development of IBDs. More than 200 genes have been shown to influence IBD susceptibility, most of which are involved in immunity. The vertebrate immune system comprises a complex network of innate and adaptive immune cells that protect the host from infection and cancer. Dysregulation of the mutualistic relationship between the immune system and the gut environment results in IBD. Considering the fundamental role of epigenetic regulation in immune cells, epigenetic mechanisms, particularly in T helper (Th) cells, may play a major role in the complex regulation of mucosal immunity. Epigenetic regulation and dysregulation of Th cells are involved in the maintenance of intestinal homeostasis and its breakdown in IBD.

Original languageEnglish
JournalSeminars in Immunopathology
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Helper-Inducer T-Lymphocytes
Inflammatory Bowel Diseases
Epigenomics
Virulence
Immune System
Immunity
Mucosal Immunity
Microbiota
Disease Susceptibility
Vertebrates
Homeostasis
Maintenance
Anti-Bacterial Agents
Inflammation
Food
Infection
Genes
Neoplasms

Keywords

  • CD4 T cell
  • Colitis
  • Epigenetic regulation
  • Inflammatory bowel disease
  • Mucosal immunology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Epigenetic regulation of T helper cells and intestinal pathogenicity. / Hagihara, Yuya; Yoshimatsu, Yusuke; Mikami, Yohei; Takada, Yoshiaki; Mizuno, Shinta; Kanai, Takanori.

In: Seminars in Immunopathology, 01.01.2019.

Research output: Contribution to journalReview article

Hagihara, Yuya ; Yoshimatsu, Yusuke ; Mikami, Yohei ; Takada, Yoshiaki ; Mizuno, Shinta ; Kanai, Takanori. / Epigenetic regulation of T helper cells and intestinal pathogenicity. In: Seminars in Immunopathology. 2019.
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