Epimerization of Aldoses Catalyzed by Dioxobis(2,4-pentanedionato-O,O′)-molybdenum (VI). An Improved Procedure for C-2 Epimer Preparation

Yoshihiro Abe, Takehisa Kunieda, Takeo Takizawa

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Epimerization of aldo-hexoses and -pentoses to the corresponding C-2 epimers Proceeds more rapidly when catalyzed by dioxobis(2,4-pentanedionato-O,O′)molybdenum (VI) in N,N-dimethylformamide than in the reported reaction with aqueous molybdic acid. Thus, on treatment at 50° for 5 hr, d-glucose or d-mannose gave an equilibrium mixture of d-glucose and d-mannose in a ratio of 55: 45.

Original languageEnglish
Pages (from-to)1324-1326
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume28
Issue number4
DOIs
Publication statusPublished - 1980
Externally publishedYes

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Keywords

  • d-glucose
  • d-mannose
  • dioxobis-(2,4-pentanedionato-O,O′)molybedenum (VI)
  • epimer
  • epimerization
  • l-arabinose
  • l-ribose

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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