Epithelial cells as sentinels in mucosal immune barrier

Kouji Hase, Hiroshi Ohno

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The mucosal surface of the body is exposed to a vast array of exogenous antigens and microorganisms. Epithelial cells evoke minimal immune response to food ingredients and commensal bacteria, while they release an array of antimicrobial peptides and CXC chemokines in response to bacterial invasion or inflammatory stimuli. The mucosal antigens are transported from the gut lumen to organized lymphoid follicles by specialized epithelial M cells residing in follicle-associated epithelium (FAE). An alternative pathway of antigen uptake with neonatal Fc receptor (FcRn) is also reported. Furthermore, intestinal dendritic cells underneath epithelium directly take up luminal antigens, where epithelial fractalkine expression plays a critical role in the guidance of dendrite extrusion. Epithelial cells express polymeric Ig receptor (pIgR) that is essential for the luminal secretion of dimeric IgA produced in the lamina propria. Furthermore, soluble factors released by mucosal epithelial cells condition dendritic cells, which in turn promote Th2 response. These multiple lines of evidence clearly suggest the significant role of epithelial cells at the front line of mucosal immune defense.

Original languageEnglish
Pages (from-to)16-26
Number of pages11
JournalNihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology
Volume29
Issue number1
DOIs
Publication statusPublished - 2006
Externally publishedYes

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Epithelial Cells
Antigens
Dendritic Cells
Polymeric Immunoglobulin Receptors
Epithelium
Chemokine CX3CL1
CXC Chemokines
Dendrites
Immunoglobulin A
Mucous Membrane
cyhalothrin
Bacteria
Food
Peptides

Cite this

Epithelial cells as sentinels in mucosal immune barrier. / Hase, Kouji; Ohno, Hiroshi.

In: Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology, Vol. 29, No. 1, 2006, p. 16-26.

Research output: Contribution to journalArticle

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