Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues

Yuuki Obata, Shunsuke Kimura, Gaku Nakato, Keito Iizuka, Yurika Miyagawa, Yutaka Nakamura, Yukihiro Furusawa, Machiko Sugiyama, Keiichiro Suzuki, Masashi Ebisawa, Yumiko Fujimura, Hisahiro Yoshida, Toshihiko Iwanaga, Koji Hase, Hiroshi Ohno

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Intrinsic Notch signaling in intestinal epithelial cells restricts secretory cell differentiation. In gut-associated lymphoid tissue (GALT), stromal cells located beneath the follicle-associated epithelium (FAE) abundantly express the Notch ligand delta-like 1 (Dll1). Here, we show that mice lacking Rbpj - a gene encoding a transcription factor implicated in Notch signaling - in intestinal epithelial cells have defective GALT maturation. This defect can be attributed to the expansion of goblet cells, which leads to the down-regulation of CCL20 in FAE. These data demonstrate that epithelial Notch signaling maintained by stromal cells contributes to the full maturation of GALT by restricting secretory cell differentiation in FAE.

Original languageEnglish
Pages (from-to)1297-1304
Number of pages8
JournalEMBO Reports
Volume15
Issue number12
DOIs
Publication statusPublished - 2014 Dec 1

Keywords

  • Notch signaling
  • follicle-associated epithelium
  • gut-associated lymphoid tissues
  • intestinal epithelial cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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  • Cite this

    Obata, Y., Kimura, S., Nakato, G., Iizuka, K., Miyagawa, Y., Nakamura, Y., Furusawa, Y., Sugiyama, M., Suzuki, K., Ebisawa, M., Fujimura, Y., Yoshida, H., Iwanaga, T., Hase, K., & Ohno, H. (2014). Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues. EMBO Reports, 15(12), 1297-1304. https://doi.org/10.15252/embr.201438942