Epstein-Barr virus-associated myelitis in a child receiving immunosuppressive therapy

Tomomi Ota, Hiroshi Asanuma, Tomohide Goto, Seiichiro Shishido, Hiroshi Hataya, Sahoko Miyama

Research output: Contribution to journalArticle

Abstract

A 10-year-old boy was admitted to the hospital complaining of a fever of 7 days' duration and myalgia. He had undergone renal transplantation at the age of seven due to chronic renal failure and had been receiving immunosuppressive agents. On admission, he complained of severe pain in his lower extremities and difficulty walking. Based on elevated serum creatine kinase, acute viral myositis was diagnosed. Seven days after admission, however, urinary incontinence as well as sensory disturbances in the hip and genitalia became evident. Based on the presence of Epstein-Barr virus (EBV) DNA in the cerebrospinal fluid and abnormal signals on MRI of the spinal cord at levels lower than Th8, EBV-associated myelitis was diagnosed. Immunosuppressive agents were reduced, and administration of immunoglobulin, ganciclovir and steroids was started. His condition gradually recovered with minimal sequelae. The antibody titer against EBV confirmed the past infection, suggesting that his myelitis might have been caused by EBV reactivation. This case indicates that reactivating EBV should be considered as a potential cause of myelitis in immunosuppressed patients.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalNo To Hattatsu
Volume49
Issue number4
Publication statusPublished - 2017

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Myelitis
Immunosuppressive Agents
Human Herpesvirus 4
Mobility Limitation
Therapeutics
Ganciclovir
Myositis
Genitalia
Myalgia
Urinary Incontinence
Creatine Kinase
Kidney Transplantation
Chronic Kidney Failure
Cerebrospinal Fluid
Immunoglobulins
Hip
Lower Extremity
Spinal Cord
Fever
Steroids

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)
  • Clinical Neurology

Cite this

Ota, T., Asanuma, H., Goto, T., Shishido, S., Hataya, H., & Miyama, S. (2017). Epstein-Barr virus-associated myelitis in a child receiving immunosuppressive therapy. No To Hattatsu, 49(4), 279-282.

Epstein-Barr virus-associated myelitis in a child receiving immunosuppressive therapy. / Ota, Tomomi; Asanuma, Hiroshi; Goto, Tomohide; Shishido, Seiichiro; Hataya, Hiroshi; Miyama, Sahoko.

In: No To Hattatsu, Vol. 49, No. 4, 2017, p. 279-282.

Research output: Contribution to journalArticle

Ota, T, Asanuma, H, Goto, T, Shishido, S, Hataya, H & Miyama, S 2017, 'Epstein-Barr virus-associated myelitis in a child receiving immunosuppressive therapy', No To Hattatsu, vol. 49, no. 4, pp. 279-282.
Ota, Tomomi ; Asanuma, Hiroshi ; Goto, Tomohide ; Shishido, Seiichiro ; Hataya, Hiroshi ; Miyama, Sahoko. / Epstein-Barr virus-associated myelitis in a child receiving immunosuppressive therapy. In: No To Hattatsu. 2017 ; Vol. 49, No. 4. pp. 279-282.
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