Epstein-Barr Virus-Associated Posttransplant Lymphoproliferative Disorder after a Cord Blood Stem Cell Transplantation Presenting with Pulmonary Nodules

Noriko Shimasaki, Tetsuya Mori, Hiroyuki Shimada, Mayumi Sugita, Masataka Higuchi, Makio Mukai, Tomohiro Morio, Shinichiro Okamoto

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6 Citations (Scopus)

Abstract

Sixteen months after a cord blood stem cell transplantation, a 6-year-old girl was diagnosed with Epstein-Barr virus-associated posttransplant lymphoproliferative disorder (EBV-PTLD). A CT scan revealed nodules in both lungs, but the patient had neither lymphadenopathy nor other lesions. The diagnosis was confirmed by histopathologic evaluation and the increased level of EBV DNA in the peripheral blood. The patient was successfully treated with rituximab, and a complete regression of the tumors was achieved. This case reveals the need to include EBV-PTLD in the differential diagnosis of pulmonary nodules, as well as demonstrating that rituximab may be effective treatment of EBV-PTLD after cord blood stem cell transplantation.

Original languageEnglish
Pages (from-to)124-127
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume26
Issue number2
DOIs
Publication statusPublished - 2004 Feb 1

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Keywords

  • Chronic graft-versus-host disease
  • Cord blood stem cell transplantation
  • Epstein-Barr virus
  • Lung
  • Posttransplant lymphoproliferative disorder
  • Rituximab

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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