Epstein-Barr virus-associated T/natural killer-cell lymphomas in the elderly: The first consensus meeting in Kofu 2013

Toshihisa Hamada, Shigeo Nakamura, Young Hyeh Ko, Tadashi Yoshino, Koichi Ohshima, Takamitsu Matsuzawa, Keiko Miura, Toshifumi Takahashi, Hisashi Nomura, Tomomi Hoshino, Daisuke Suzuki, Shinji Shimada, Keiji Iwatsuki

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3 Citations (Scopus)

Abstract

From a clinicopathological conference on nine elderly patients with Epstein-Barr virus (EBV)-associated T/natural killer (NK)-cell lymphoma, we have addressed the patients' backgrounds, clinical manifestations, histopathological findings, cytogenesis, complications and prognoses. Among these elderly patients (>65 years old), seven patients had extranodal NK/T-cell lymphoma, nasal type (ENKL) with an NK-cell phenotype, and two patients had EBV + T-cell lymphomas or lymphoproliferative disorders (LPD) with cutaneous lesions mimicking pityriasis lichenoides et varioliformis acuta (PLEVA) or hydroa vacciniforme (HV). No patients had a previous episode of EBV-related symptoms such as infectious mononucleosis, chronic active EBV infection, HV or hypersensitivity to mosquito bites. Elderly patients with ENKL may show the centroblastoid variant. EBV+CD8+CD56 +/- lymphocytes may be responsible for the development of PLEVA or HV-like cutaneous lesions in the elderly.

Original languageEnglish
Pages (from-to)40-42
Number of pages3
JournalJournal of Dermatology
Volume41
Issue number1
DOIs
Publication statusPublished - 2014 Jan

Keywords

  • Epstein-Barr virus
  • T/natural killer-cell lymphoma
  • centroblastoid
  • hydroa vacciniforme
  • nasal type

ASJC Scopus subject areas

  • Dermatology

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  • Cite this

    Hamada, T., Nakamura, S., Ko, Y. H., Yoshino, T., Ohshima, K., Matsuzawa, T., Miura, K., Takahashi, T., Nomura, H., Hoshino, T., Suzuki, D., Shimada, S., & Iwatsuki, K. (2014). Epstein-Barr virus-associated T/natural killer-cell lymphomas in the elderly: The first consensus meeting in Kofu 2013. Journal of Dermatology, 41(1), 40-42. https://doi.org/10.1111/1346-8138.12373