ERK2 mediates inner hair cell survival and decreases susceptibility to noise-induced hearing loss

Takaomi Kurioka, Takeshi Matsunobu, Yasushi Satoh, Katsuki Niwa, Shogo Endo, Masato Fujioka, Akihiro Shiotani

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Extracellular signal-regulated kinase (ERK) is a member of the family of mitogen-activated protein kinases (MAPKs) and coordinately regulates a multitude of cellular processes. In response to a variety of extracellular stimuli, phosphorylation of both threonine and tyrosine residues activates ERK. Recent evidence indicates that ERK is activated in response to cellular stress such as acoustic trauma. However, the specific role of ERK isoforms in auditory function is not fully understood. Here, we show that the isoform ERK2 plays an important role in regulating hair cell (HC) survival and noise-induced hearing loss (NIHL) in mice (C57BL/6J). We found that conditional knockout mice deficient for Erk2 in the inner ear HCs had hearing comparable to control mice and exhibited no HC loss under normal conditions. However, we found that these knockout mice were more vulnerable to noise and had blunted recovery from NIHL compared to control mice. Furthermore, we observed a significantly lower survival rate of inner hair cells in these mice compared to control mice. Our results indicate that ERK2 plays important roles in the survival of HC in NIHL.

Original languageEnglish
Article number16839
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - 2015 Nov 18

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Inner Auditory Hair Cells
Noise-Induced Hearing Loss
Extracellular Signal-Regulated MAP Kinases
Cell Survival
Knockout Mice
Protein Isoforms
Alopecia
Inner Ear
Threonine
Mitogen-Activated Protein Kinases
Inbred C57BL Mouse
Hearing
Tyrosine
Noise
Survival Rate
Phosphorylation

ASJC Scopus subject areas

  • General

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ERK2 mediates inner hair cell survival and decreases susceptibility to noise-induced hearing loss. / Kurioka, Takaomi; Matsunobu, Takeshi; Satoh, Yasushi; Niwa, Katsuki; Endo, Shogo; Fujioka, Masato; Shiotani, Akihiro.

In: Scientific Reports, Vol. 5, 16839, 18.11.2015.

Research output: Contribution to journalArticle

Kurioka, Takaomi ; Matsunobu, Takeshi ; Satoh, Yasushi ; Niwa, Katsuki ; Endo, Shogo ; Fujioka, Masato ; Shiotani, Akihiro. / ERK2 mediates inner hair cell survival and decreases susceptibility to noise-induced hearing loss. In: Scientific Reports. 2015 ; Vol. 5.
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