Erythroid and granulocyte/macrophage progenitor cells in primary acquired sideroblastic anemia

H. Mizoguchi, K. Kubota, T. Suda, F. Takaku, Y. Miura

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In order to study the pathogenesis of primary acquired sideroblastic anemia (PASA), bone marrow and/or peripheral blood specimens obtained from four patients with PASA were cultured for erythroid colony-forming units (CFU-E), erythroid burst-forming units (BFU-E), and granulocyte/macrophage colony-forming units (GM-CFU). The number of CFU-E was markedly decreased in all four patients. CFU-E colonies consisted exclusively of normal-appearing erythroblasts, while ringed sideroblasts were observed only in scattered single erythroblasts or in small erythroblast aggregates. In one case, very few BFU-E colonies containing both normal-appearing erythroblasts and ringed sideroblasts were detected. In addition, the number of GM-CFU was significantly decreased in three out of the four cases. These findings may suggest that there are abnormalities in the pluripotent hemopoietic stem cells at least in some cases of PASA.

Original languageEnglish
Pages (from-to)15-23
Number of pages9
JournalInternational Journal of Cell Cloning
Volume1
Issue number1
Publication statusPublished - 1983

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Sideroblastic Anemia
Granulocyte-Macrophage Progenitor Cells
Erythroid Precursor Cells
Erythroblasts
Pluripotent Stem Cells
Bone Marrow

ASJC Scopus subject areas

  • Cell Biology

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Erythroid and granulocyte/macrophage progenitor cells in primary acquired sideroblastic anemia. / Mizoguchi, H.; Kubota, K.; Suda, T.; Takaku, F.; Miura, Y.

In: International Journal of Cell Cloning, Vol. 1, No. 1, 1983, p. 15-23.

Research output: Contribution to journalArticle

Mizoguchi, H, Kubota, K, Suda, T, Takaku, F & Miura, Y 1983, 'Erythroid and granulocyte/macrophage progenitor cells in primary acquired sideroblastic anemia', International Journal of Cell Cloning, vol. 1, no. 1, pp. 15-23.
Mizoguchi, H. ; Kubota, K. ; Suda, T. ; Takaku, F. ; Miura, Y. / Erythroid and granulocyte/macrophage progenitor cells in primary acquired sideroblastic anemia. In: International Journal of Cell Cloning. 1983 ; Vol. 1, No. 1. pp. 15-23.
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