TY - JOUR
T1 - Erythroid and granulocyte/macrophage progenitor cells in primary acquired sideroblastic anemia
AU - Mizoguchi, Hideaki
AU - Kubota, Kazuo
AU - Suda, Toshio
AU - Takaku, Fumimaro
AU - Miura, Yasusada
PY - 1983
Y1 - 1983
N2 - In order to study the pathogenesis of primary acquired sideroblastic anemia (PASA), bone marrow and/or peripheral blood specimens obtained from four patients with PASA were cultured for erythroid colony‐forming units (CFU‐E), erythroid burst‐forming units (BFU‐E), and granulocyte/macrophage colony‐forming units (GM‐CFU). The number of CFU‐E was markedly decreased in all four patients. CFU‐E colonies consisted exclusively of normal‐appearing erythroblasts, while ringed sideroblasts were observed only in scattered single erythroblasts or in small erythroblast aggregates. In one case, very few BFU‐E colonies containing both normal‐appearing erythroblasts and ringed sideroblasts were detected. In addition, the number of GM‐CFU was significantly decreased in three out of the four cases. These findings may suggest that there are abnormalities in the pluripotent hemopoietic stem cells at least in some cases of PASA.
AB - In order to study the pathogenesis of primary acquired sideroblastic anemia (PASA), bone marrow and/or peripheral blood specimens obtained from four patients with PASA were cultured for erythroid colony‐forming units (CFU‐E), erythroid burst‐forming units (BFU‐E), and granulocyte/macrophage colony‐forming units (GM‐CFU). The number of CFU‐E was markedly decreased in all four patients. CFU‐E colonies consisted exclusively of normal‐appearing erythroblasts, while ringed sideroblasts were observed only in scattered single erythroblasts or in small erythroblast aggregates. In one case, very few BFU‐E colonies containing both normal‐appearing erythroblasts and ringed sideroblasts were detected. In addition, the number of GM‐CFU was significantly decreased in three out of the four cases. These findings may suggest that there are abnormalities in the pluripotent hemopoietic stem cells at least in some cases of PASA.
KW - BFU‐E
KW - CFU‐E
KW - GM‐CFU
KW - Sideroblastic anemia
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U2 - 10.1002/stem.5530010104
DO - 10.1002/stem.5530010104
M3 - Article
C2 - 6674386
AN - SCOPUS:0020959156
VL - 1
SP - 15
EP - 23
JO - International Journal of Cell Cloning
JF - International Journal of Cell Cloning
SN - 1066-5099
IS - 1
ER -