Abstract
In order to study the pathogenesis of primary acquired sideroblastic anemia (PASA), bone marrow and/or peripheral blood specimens obtained from four patients with PASA were cultured for erythroid colony-forming units (CFU-E), erythroid burst-forming units (BFU-E), and granulocyte/macrophage colony-forming units (GM-CFU). The number of CFU-E was markedly decreased in all four patients. CFU-E colonies consisted exclusively of normal-appearing erythroblasts, while ringed sideroblasts were observed only in scattered single erythroblasts or in small erythroblast aggregates. In one case, very few BFU-E colonies containing both normal-appearing erythroblasts and ringed sideroblasts were detected. In addition, the number of GM-CFU was significantly decreased in three out of the four cases. These findings may suggest that there are abnormalities in the pluripotent hemopoietic stem cells at least in some cases of PASA.
| Original language | English |
|---|---|
| Pages (from-to) | 15-23 |
| Number of pages | 9 |
| Journal | International Journal of Cell Cloning |
| Volume | 1 |
| Issue number | 1 |
| Publication status | Published - 1983 |
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ASJC Scopus subject areas
- Cell Biology
Cite this
Erythroid and granulocyte/macrophage progenitor cells in primary acquired sideroblastic anemia. / Mizoguchi, H.; Kubota, K.; Suda, T.; Takaku, F.; Miura, Y.
In: International Journal of Cell Cloning, Vol. 1, No. 1, 1983, p. 15-23.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Erythroid and granulocyte/macrophage progenitor cells in primary acquired sideroblastic anemia
AU - Mizoguchi, H.
AU - Kubota, K.
AU - Suda, T.
AU - Takaku, F.
AU - Miura, Y.
PY - 1983
Y1 - 1983
N2 - In order to study the pathogenesis of primary acquired sideroblastic anemia (PASA), bone marrow and/or peripheral blood specimens obtained from four patients with PASA were cultured for erythroid colony-forming units (CFU-E), erythroid burst-forming units (BFU-E), and granulocyte/macrophage colony-forming units (GM-CFU). The number of CFU-E was markedly decreased in all four patients. CFU-E colonies consisted exclusively of normal-appearing erythroblasts, while ringed sideroblasts were observed only in scattered single erythroblasts or in small erythroblast aggregates. In one case, very few BFU-E colonies containing both normal-appearing erythroblasts and ringed sideroblasts were detected. In addition, the number of GM-CFU was significantly decreased in three out of the four cases. These findings may suggest that there are abnormalities in the pluripotent hemopoietic stem cells at least in some cases of PASA.
AB - In order to study the pathogenesis of primary acquired sideroblastic anemia (PASA), bone marrow and/or peripheral blood specimens obtained from four patients with PASA were cultured for erythroid colony-forming units (CFU-E), erythroid burst-forming units (BFU-E), and granulocyte/macrophage colony-forming units (GM-CFU). The number of CFU-E was markedly decreased in all four patients. CFU-E colonies consisted exclusively of normal-appearing erythroblasts, while ringed sideroblasts were observed only in scattered single erythroblasts or in small erythroblast aggregates. In one case, very few BFU-E colonies containing both normal-appearing erythroblasts and ringed sideroblasts were detected. In addition, the number of GM-CFU was significantly decreased in three out of the four cases. These findings may suggest that there are abnormalities in the pluripotent hemopoietic stem cells at least in some cases of PASA.
UR - http://www.scopus.com/inward/record.url?scp=0020959156&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020959156&partnerID=8YFLogxK
M3 - Article
C2 - 6674386
AN - SCOPUS:0020959156
VL - 1
SP - 15
EP - 23
JO - Stem Cells
JF - Stem Cells
SN - 1066-5099
IS - 1
ER -