Esophageal basaloid carcinoma with marked myoepithelial differentiation

Tomoyuki Hishida, Yukihiro Nakanishi, Tadakazu Shimoda, Hiroyasu Igaki, Yuji Tachimori, Hoichi Kato, Hajime Yamaguchi, Gen Iinuma

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A case of esophageal basaloid carcinoma with marked myoepithelial differentiation in a 60-year-old man is reported. The tumor arose as an exophytic mass, measuring 65 × 60 mm, in the middle thoracic esophagus. Approximately two-thirds of the tumor surface was covered with non-cancerous esophageal epithelium. The depth of tumor invasion was limited to the submucosal layer. Histologically, about 70% of the tumor contained a typical basaloid carcinoma component and about 30% contained glandular and intercalated duct-like components with distinct epithelial and myoepithelial differentiation. The tumor presented no component of distinct squamous cell carcinoma, but a small portion of cribriform-like structure, which is typical of adenoid cystic carcinoma, was visible. The inner epithelium composing the intercalated duct-like structure showed immunohistochemical positivity for cytokeratin 14, and the outer epithelium lining adjacent to the stroma showed positivity for α-smooth muscle actin. These findings supported epithelial/myoepithelial differentiation. To our knowledge, our case is the first patient with an esophageal basaloid carcinoma showing marked myoepithelial differentiation.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalPathology International
Volume52
Issue number4
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Carcinoma
Epithelium
Neoplasms
Keratin-14
Adenoid Cystic Carcinoma
Esophagus
Smooth Muscle
Actins
Squamous Cell Carcinoma
Thorax

Keywords

  • Basaloid carcinoma
  • Ductal differentiation
  • Esophagus
  • Myoepithelial differentiation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Hishida, T., Nakanishi, Y., Shimoda, T., Igaki, H., Tachimori, Y., Kato, H., ... Iinuma, G. (2002). Esophageal basaloid carcinoma with marked myoepithelial differentiation. Pathology International, 52(4), 313-317. https://doi.org/10.1046/j.1440-1827.2002.01346.x

Esophageal basaloid carcinoma with marked myoepithelial differentiation. / Hishida, Tomoyuki; Nakanishi, Yukihiro; Shimoda, Tadakazu; Igaki, Hiroyasu; Tachimori, Yuji; Kato, Hoichi; Yamaguchi, Hajime; Iinuma, Gen.

In: Pathology International, Vol. 52, No. 4, 2002, p. 313-317.

Research output: Contribution to journalArticle

Hishida, T, Nakanishi, Y, Shimoda, T, Igaki, H, Tachimori, Y, Kato, H, Yamaguchi, H & Iinuma, G 2002, 'Esophageal basaloid carcinoma with marked myoepithelial differentiation', Pathology International, vol. 52, no. 4, pp. 313-317. https://doi.org/10.1046/j.1440-1827.2002.01346.x
Hishida, Tomoyuki ; Nakanishi, Yukihiro ; Shimoda, Tadakazu ; Igaki, Hiroyasu ; Tachimori, Yuji ; Kato, Hoichi ; Yamaguchi, Hajime ; Iinuma, Gen. / Esophageal basaloid carcinoma with marked myoepithelial differentiation. In: Pathology International. 2002 ; Vol. 52, No. 4. pp. 313-317.
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