Esophageal early basaloid squamous carcinoma with unusual narrowband imaging magnified endoscopy findings

Yugo Kai, Motohiko Kato, Yoshito Hayashi, Tomofumi Akasaka, Shinichiro Shinzaki, Tsutomu Nishida, Masahiko Tsujii, Eiichi Morii, Tetsuo Takehara

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Basaloid squamous carcinoma (BSC) is a rare variant of esophageal cancer. There are very few reports of "early" BSC. Here we report a case of early BSC with unusual findings by narrowband imaging magnified endoscopy (NBI-ME). A 70-year-old man with a middle thoracic esophageal tumor was referred to our hospital. White-light endoscopy revealed a reddish depressed lesion 5 mm in diameter having a subepithelial tumor-like prominence with a gentle rising slope. NBI-ME revealed irregular loop-shaped microvessels coexistent with thick irregularly branched non-looped vessels. Iodine staining revealed a pale brown lesion. We performed endoscopic submucosal dissection for diagnostic treatment. Histologic examination showed the proliferation of basal cell-like hyperchromatic tumor cells in the lamina propria and with slight invasion into the submucosa at a depth of 320 μm. The tumor cells formed solid nests and microcystic structures, containing an Alcian blue-positive mucoid matrix. The surface was covered with squamous epithelium without cellular atypia. Thin vessels were observed in the intra-epithelial papilla and thick vessels were observed around the solid nests beneath the epithelium. Based on these findings together, we diagnosed the lesion as BSC. In this case, the NBI-ME findings differed from those of typical squamous cell carcinoma in that both non-invasive cancer-like irregular loop-shaped microvessels coexisted with massively invasive cancerlike thick non-looped vessels. We speculate that the looped and non-looped vessels observed by NBI-ME histologically corresponded to thin vessels in the intraepithelial papilla and thick vessels around the tumor nests, respectively. These NBI-ME findings might be a feature of early esophageal BSC.

Original languageEnglish
Pages (from-to)12673-12677
Number of pages5
JournalWorld Journal of Gastroenterology
Volume20
Issue number35
DOIs
Publication statusPublished - 2014 Sep 21
Externally publishedYes

Fingerprint

Narrow Band Imaging
Endoscopy
Squamous Cell Carcinoma
Neoplasms
Microvessels
Epithelium
Alcian Blue
Esophageal Neoplasms
Iodine
Mucous Membrane
Thorax
Cell Proliferation
Staining and Labeling
Light

Keywords

  • Basaloid squamous carcinoma
  • Endoscopic submucosal dissection
  • Esophagus
  • Narrowband imaging

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Kai, Y., Kato, M., Hayashi, Y., Akasaka, T., Shinzaki, S., Nishida, T., ... Takehara, T. (2014). Esophageal early basaloid squamous carcinoma with unusual narrowband imaging magnified endoscopy findings. World Journal of Gastroenterology, 20(35), 12673-12677. https://doi.org/10.3748/wjg.v20.i35.12673

Esophageal early basaloid squamous carcinoma with unusual narrowband imaging magnified endoscopy findings. / Kai, Yugo; Kato, Motohiko; Hayashi, Yoshito; Akasaka, Tomofumi; Shinzaki, Shinichiro; Nishida, Tsutomu; Tsujii, Masahiko; Morii, Eiichi; Takehara, Tetsuo.

In: World Journal of Gastroenterology, Vol. 20, No. 35, 21.09.2014, p. 12673-12677.

Research output: Contribution to journalArticle

Kai, Y, Kato, M, Hayashi, Y, Akasaka, T, Shinzaki, S, Nishida, T, Tsujii, M, Morii, E & Takehara, T 2014, 'Esophageal early basaloid squamous carcinoma with unusual narrowband imaging magnified endoscopy findings', World Journal of Gastroenterology, vol. 20, no. 35, pp. 12673-12677. https://doi.org/10.3748/wjg.v20.i35.12673
Kai, Yugo ; Kato, Motohiko ; Hayashi, Yoshito ; Akasaka, Tomofumi ; Shinzaki, Shinichiro ; Nishida, Tsutomu ; Tsujii, Masahiko ; Morii, Eiichi ; Takehara, Tetsuo. / Esophageal early basaloid squamous carcinoma with unusual narrowband imaging magnified endoscopy findings. In: World Journal of Gastroenterology. 2014 ; Vol. 20, No. 35. pp. 12673-12677.
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